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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
C3H/HeJ mice develop an increase in terminal air space area detectable by postnatal d 14 that persists into adulthood compared with strain-matched controls (C3H/SnJ, C3H/OuJ). Morphometric quantification revealed a 50% increase in terminal air space area by postnatal d 14 and a 2.3-fold increase by 2 mo of age in C3H/HeJ mice. Bacteriologic cultures obtained from the left lung on postnatal d 7 revealed > 100 colony-forming units (CFU)/left lung of predominantly Gram-negative bacteria (GNB) (Escherichia coli and Proteus mirabilis) in 13 of the 14 C3H/HeJ mice compared with 0 of 12 controls demonstrating colonization of the developing lung in C3H/HeJ mice. An approximately threefold increase in macrophages from bronchoalveolar lavage, threefold increases in matrix metalloproteinase 12 (MMP-12) mRNA and protein levels and elevated levels of proinflammatory cytokines monocyte chemoattractant protein (MCP-1) and keratinocyte-derived cytokine (KC) were also found. P. mirabilis obtained from lung cultures in C3H/HeJ mice induced nuclear factor-kappaB (NF-kappaB) activation in human embryonic kidney 293 (HEK 293) cells transfected with TLR5. In C3H/HeJ mice lacking TLR4 signaling, bacterial colonization is associated with chronic inflammation and permanent changes in lung morphology.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Ccl2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokine CCL2,
http://linkedlifedata.com/resource/pubmed/chemical/Chemokines,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 12,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 4,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 5,
http://linkedlifedata.com/resource/pubmed/chemical/keratinocyte-derived chemokines
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0031-3998
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
60
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
663-8
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17065580-Animals,
pubmed-meshheading:17065580-Bronchoalveolar Lavage,
pubmed-meshheading:17065580-Cell Line,
pubmed-meshheading:17065580-Chemokine CCL2,
pubmed-meshheading:17065580-Chemokines,
pubmed-meshheading:17065580-Escherichia coli,
pubmed-meshheading:17065580-Gene Expression Regulation,
pubmed-meshheading:17065580-Humans,
pubmed-meshheading:17065580-Lung,
pubmed-meshheading:17065580-Lung Diseases,
pubmed-meshheading:17065580-Lung Volume Measurements,
pubmed-meshheading:17065580-Macrophages, Alveolar,
pubmed-meshheading:17065580-Matrix Metalloproteinase 12,
pubmed-meshheading:17065580-Mice,
pubmed-meshheading:17065580-Mice, Inbred C3H,
pubmed-meshheading:17065580-NF-kappa B,
pubmed-meshheading:17065580-Proteus mirabilis,
pubmed-meshheading:17065580-RNA, Messenger,
pubmed-meshheading:17065580-Toll-Like Receptor 4,
pubmed-meshheading:17065580-Toll-Like Receptor 5
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pubmed:year |
2006
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pubmed:articleTitle |
Altered postnatal lung development in C3H/HeJ mice.
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pubmed:affiliation |
Division of Pulmonary Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 45229, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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