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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-10-26
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pubmed:abstractText |
FVB/N is considered an ideal inbred mouse strain for transgenic mouse production because of the ease of pronuclear microinjection and its overall fecundity. It is well established that vertebrate lens fiber cells normally express a modified intermediate filament network consisting of the proteins filensin and CP49, and it was recently reported that the mouse strain 129 harbors mutations in CP49 that have the potential to confound the interpretation of gene knockout studies of the lens. The purpose of this study was to evaluate the status of the CP49/Bfsp2 gene in the FVB/N strain.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0146-0404
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
47
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
4931-4
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17065509-Animals,
pubmed-meshheading:17065509-Cataract,
pubmed-meshheading:17065509-Eye Proteins,
pubmed-meshheading:17065509-Gene Deletion,
pubmed-meshheading:17065509-Genotype,
pubmed-meshheading:17065509-Intermediate Filament Proteins,
pubmed-meshheading:17065509-Lens, Crystalline,
pubmed-meshheading:17065509-Mice,
pubmed-meshheading:17065509-Mice, Inbred C57BL,
pubmed-meshheading:17065509-Mice, Mutant Strains,
pubmed-meshheading:17065509-Microscopy, Fluorescence,
pubmed-meshheading:17065509-Mutation,
pubmed-meshheading:17065509-RNA, Messenger,
pubmed-meshheading:17065509-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2006
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pubmed:articleTitle |
Inbred FVB/N mice are mutant at the cp49/Bfsp2 locus and lack beaded filament proteins in the lens.
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pubmed:affiliation |
Department of Biological Sciences, University of Delaware, Newark, DE 19716, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural,
Research Support, N.I.H., Intramural
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