rdf:type |
|
lifeskim:mentions |
umls-concept:C0001811,
umls-concept:C0018619,
umls-concept:C0019682,
umls-concept:C0019699,
umls-concept:C0019704,
umls-concept:C0205494,
umls-concept:C0243009,
umls-concept:C0449438,
umls-concept:C0521116,
umls-concept:C0599755,
umls-concept:C1332714,
umls-concept:C1516691,
umls-concept:C1708760,
umls-concept:C2698872
|
pubmed:issue |
5
|
pubmed:dateCreated |
2006-10-26
|
pubmed:abstractText |
Low CD4 lymphocyte count was a marker for neurological disease in human immunodeficiency virus type 1 (HIV-1); but is now less common among patients with access to highly active antiretroviral therapy. In this study, the authors determine the reliability of self-reported CD4 nadir and its predictive value for neurological status. The authors identify a high degree of reliability (r = .90). After adjusting for age, current CD4 count, and duration of HIV-1, CD4 nadir relates to a current diagnosis of HIV-associated dimentia (HAD) (odds ratio [OR]: 1.395 (1.106-1.761), P = .005) and distal symmetric polyneuropathy (DSPN) (OR: 1.479 (1.221-1.769, P < .001).
|
pubmed:grant |
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:status |
MEDLINE
|
pubmed:month |
Oct
|
pubmed:issn |
1355-0284
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
12
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
387-91
|
pubmed:dateRevised |
2007-12-3
|
pubmed:meshHeading |
pubmed-meshheading:17065131-Acquired Immunodeficiency Syndrome,
pubmed-meshheading:17065131-Aging,
pubmed-meshheading:17065131-Antiretroviral Therapy, Highly Active,
pubmed-meshheading:17065131-CD4 Lymphocyte Count,
pubmed-meshheading:17065131-Cognition Disorders,
pubmed-meshheading:17065131-Cohort Studies,
pubmed-meshheading:17065131-Ethnic Groups,
pubmed-meshheading:17065131-Female,
pubmed-meshheading:17065131-HIV Infections,
pubmed-meshheading:17065131-Hawaii,
pubmed-meshheading:17065131-Humans,
pubmed-meshheading:17065131-Male,
pubmed-meshheading:17065131-Middle Aged,
pubmed-meshheading:17065131-Predictive Value of Tests,
pubmed-meshheading:17065131-Treatment Outcome
|
pubmed:year |
2006
|
pubmed:articleTitle |
Lowest ever CD4 lymphocyte count (CD4 nadir) as a predictor of current cognitive and neurological status in human immunodeficiency virus type 1 infection--The Hawaii Aging with HIV Cohort.
|
pubmed:affiliation |
Hawaii AIDS Clinical Research Program, University of Hawaii, Honolulu, Hawaii, USA. Vvalcour@hawaii.edu
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|