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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-15
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pubmed:abstractText |
A series of novel mGluR1 antagonists have been prepared. Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chemical series. A chemistry driven second library iteration, covering a greatly enhanced area of chemical space, maintained good potency and introduced metabolic stability.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:DoddPeter GPG,
pubmed-author:GaytonSimonS,
pubmed-author:GreenerBen SBS,
pubmed-author:HarbottleGareth WGW,
pubmed-author:MantellSimon JSJ,
pubmed-author:MawGraham NGN,
pubmed-author:OsborneSimon ASA,
pubmed-author:OwenDafydd RDR,
pubmed-author:ReesHuwH,
pubmed-author:RingerTracy JTJ,
pubmed-author:Rodriguez-LensMargaritaM,
pubmed-author:SmithGraham FGF
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
486-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17064898-Animals,
pubmed-meshheading:17064898-Binding, Competitive,
pubmed-meshheading:17064898-CHO Cells,
pubmed-meshheading:17064898-Chemistry, Physical,
pubmed-meshheading:17064898-Chronic Disease,
pubmed-meshheading:17064898-Cricetinae,
pubmed-meshheading:17064898-Cricetulus,
pubmed-meshheading:17064898-Dose-Response Relationship, Drug,
pubmed-meshheading:17064898-Glutamic Acid,
pubmed-meshheading:17064898-Pain,
pubmed-meshheading:17064898-Physicochemical Phenomena,
pubmed-meshheading:17064898-Pyrazines,
pubmed-meshheading:17064898-Rats,
pubmed-meshheading:17064898-Receptors, Metabotropic Glutamate,
pubmed-meshheading:17064898-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Structure-activity relationships of novel non-competitive mGluR1 antagonists: a potential treatment for chronic pain.
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pubmed:affiliation |
Pfizer Global Research and Development, Ramsgate Road, Sandwich, CT13 9NJ, UK. dafydd.owen@pfizer.com
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pubmed:publicationType |
Journal Article
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