Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2007-2-7
pubmed:abstractText
The antiapoptotic protein Mcl-1, a member of the Bcl-2 family, plays critical roles in promoting the survival of lymphocytes and hematopoietic stem cells. Although previous studies have implicated Mcl-1 in regulating the survival of neutrophils and macrophages, the in vivo function of Mcl-1 in these 2 cell lineages remained unclear. To address this, we have generated mice conditionally lacking Mcl-1 expression in neutrophils and macrophages. We show that Mcl-1 conditional knockout mice had a severe defect in neutrophil survival, whereas macrophage survival was normal. The granulocyte compartment in the blood, spleen, and bone marrow of Mcl-1 conditional knockout mice exhibited an approximately 2- to 3-fold higher apoptotic rate than control cells. In contrast, resting and activated macrophages from Mcl-1-deficient mice exhibited normal survival and contained up-regulated expression of Bcl-2 and Bcl-xL. These data suggest that Mcl-1 plays a nonredundant role in promoting the survival of neutrophils but not macrophages.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-10576740, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-10621974, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-10640272, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-10914504, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-11105051, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-11457886, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-11698499, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-11801684, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-12414721, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-12433687, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-12459483, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-12637318, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-14633975, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-14668867, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-14691481, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15077116, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15078892, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15157168, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15650769, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15718471, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-15749901, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-16246265, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-16393981, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-7682708, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9002967, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9671497, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9731710, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9746790, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9787159, http://linkedlifedata.com/resource/pubmed/commentcorrection/17062731-9841913
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0006-4971
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1620-6
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.
pubmed:affiliation
Department of Immunology, Duke University Medical Center, Durham, NC 27710, USA.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural