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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
1991-4-17
|
| pubmed:abstractText |
Tubular function was measured by lithium clearance (CLi) and by its derived formulae before and after the transient increase (lasting 90 min) in glomerular filtration rate (GFR) following a meat meal (2g protein/kg body weight) in 12 normal children. Three baseline and 4 clearances after the meal were obtained, each lasting 30 min. The mean baseline CLi was 23.1 +/- 1.64 ml/min/1.73 m2. At peak GFR response (60 min from starting the meal), CLi averaged 27.6 +/- 2.4 ml/min/1.73 m2 (p less than 0.025 vs. baseline) and it was further increased (32.2 +/- 5.04 ml/min/1.73 m2, p less than 0.01 vs. baseline) 120 min after starting the meal, while GFR returned to baseline values. Fractional lithium excretion averaged 0.23 +/- 0.04 at baseline and increased continuously after the meat meal and, at completion of the study, it averaged 0.38 +/- 0.07 (p less than 0.025 vs. baseline). The distal absolute and fractional sodium reabsorption increased throughout the studies following the meal and peaked at 120 min. The functional changes were associated with a statistically significant increase in the plasma concentration of insulin, glucagon, and total amino acids after the meal. The latter at the end of the study was almost doubled (5,600 +/- 780 versus 3,200 microM at baseline, p less than 0.01). The data indicate that the tubulo glomerular feedback mechanism operates normally after a meat meal. The finding on increased distal sodium reabsorption might point to the existence of an insulin-dependent mechanism.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Aldosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Amino Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Dietary Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Glucagon,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Hormones,
http://linkedlifedata.com/resource/pubmed/chemical/Insulin,
http://linkedlifedata.com/resource/pubmed/chemical/Lithium
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1011-6524
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
N
|
| pubmed:pagination |
63-70
|
| pubmed:dateRevised |
2011-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1706107-Aldosterone,
pubmed-meshheading:1706107-Amino Acids,
pubmed-meshheading:1706107-Child,
pubmed-meshheading:1706107-Dietary Proteins,
pubmed-meshheading:1706107-Female,
pubmed-meshheading:1706107-Glomerular Filtration Rate,
pubmed-meshheading:1706107-Glucagon,
pubmed-meshheading:1706107-Growth Hormone,
pubmed-meshheading:1706107-Hematocrit,
pubmed-meshheading:1706107-Hormones,
pubmed-meshheading:1706107-Humans,
pubmed-meshheading:1706107-Insulin,
pubmed-meshheading:1706107-Kidney Tubules,
pubmed-meshheading:1706107-Lithium,
pubmed-meshheading:1706107-Male,
pubmed-meshheading:1706107-Meat,
pubmed-meshheading:1706107-Metabolic Clearance Rate,
pubmed-meshheading:1706107-Renal Circulation,
pubmed-meshheading:1706107-Vascular Resistance
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Tubular function by lithium clearance, plasma amino acids and hormones following a meat meal in childhood.
|
| pubmed:affiliation |
Department of Pediatrics, Federico II University, Naples, Italy.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|