Linked Life Data

1706097

Source:http://linkedlifedata.com/resource/pubmed/id/1706097

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1304
pubmed:dateCreated
1991-4-12
pubmed:abstractText
Whole-cell patch-clamp recordings were obtained from light-responsive on-bipolar cells in retinal slices of the dogfish. Inclusion of the G-protein activator, GTP gamma S, in the intracellular patch solution mimicked the action of glutamate, inducing an increase in net outward current (interpreted as a decrease in inward current), a decrease in membrane conductance and block of light responses. Cyclic GMP (cGMP) in the patch pipette increased inward current and membrane conductance, and blocked light responses. Cyclic AMP had no effect. IBMX, a phosphodiesterase inhibitor, produced the same effect as cGMP, suggesting the presence of a cGMP phosphodiesterase in rod bipolar cells. These results indicate that the glutamate receptors of on-bipolar cells are coupled via a G-protein to regulate intracellular cGMP, which, in turn, results in the opening of sub-synaptic membrane channels. The similarity to phototransduction is striking, and the proposed scheme would account for the high gain in transmission of rod signals to on-bipolar cells.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0962-8452
pubmed:author
pubmed:issnType
Print
pubmed:day
22
pubmed:volume
242
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
91-4
pubmed:dateRevised
2009-9-29
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
Glutamate receptors of rod bipolar cells are linked to a cyclic GMP cascade via a G-protein.
pubmed:affiliation
Physiology Department, University College London, U.K.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't