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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
8
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|
pubmed:dateCreated |
2006-10-24
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pubmed:abstractText |
Lrrk2 G2019S is predominantly associated with alpha-synuclein-immunopositive Lewy body pathology. We have identified Family SK where Lrrk2 G2019S segregates with slowly progressive parkinsonism and the affected proband has tau-immunopositive neurofibrillary tangle pathology. Thus alpha-synucleinopathy and tauopathy, the predominant pathologies associated with parkinsonism, may be alternate outcomes of the same underlying genetic cause. Intriguingly, we observe no evidence of a direct interaction between either the tau or alpha-synuclein protein with Lrrk2.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
AIM
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|
pubmed:chemical |
|
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pubmed:status |
MEDLINE
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|
pubmed:month |
Oct
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|
pubmed:issn |
1526-632X
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pubmed:author |
|
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pubmed:issnType |
Electronic
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pubmed:day |
24
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pubmed:volume |
67
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pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1506-8
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17060589-Aged,
pubmed-meshheading:17060589-Brain,
pubmed-meshheading:17060589-Cell Line,
pubmed-meshheading:17060589-Disability Evaluation,
pubmed-meshheading:17060589-Disease Progression,
pubmed-meshheading:17060589-Female,
pubmed-meshheading:17060589-Glycine,
pubmed-meshheading:17060589-Humans,
pubmed-meshheading:17060589-Immunohistochemistry,
pubmed-meshheading:17060589-Male,
pubmed-meshheading:17060589-Middle Aged,
pubmed-meshheading:17060589-Mutation,
pubmed-meshheading:17060589-Neurofibrillary Tangles,
pubmed-meshheading:17060589-Parkinsonian Disorders,
pubmed-meshheading:17060589-Pedigree,
pubmed-meshheading:17060589-Protein-Serine-Threonine Kinases,
pubmed-meshheading:17060589-Serine,
pubmed-meshheading:17060589-alpha-Synuclein,
pubmed-meshheading:17060589-tau Proteins
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|
pubmed:year |
2006
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|
pubmed:articleTitle |
Parkinsonism, Lrrk2 G2019S, and tau neuropathology.
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|
pubmed:affiliation |
Division of Neurology, University of Saskatchewan and Saskatoon Health Region, Saskatoon, Saskatchewan, Canada.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, N.I.H., Extramural
|
