Linked Life Data

1705907

Source:http://linkedlifedata.com/resource/pubmed/id/1705907

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1991-4-17
pubmed:abstractText
The regulation of anaphylaxis-mediated fluid secretion by the small intestine was examined in rats immunized by infection with Trichinella spiralis and reinfected by intraduodenal injection with L1 larvae. Net fluid secretion, which was measured as the volume of fluid present in the intestine 30 minutes after the challenge infection, was significantly greater in both actively and passively immunized rats than in nonimmune rats. The amount of fluid recovered from the immune host was equivalent to that secreted in response to 50 micrograms/kg of prostaglandin E2 or 250 micrograms/kg of cholera toxin. Worm-induced fluid secretion in immune hosts was reduced by treatment with diphenhydramine and inhibited by the dual application of diphenhydramine and indomethacin. Indomethacin alone had no effect despite inhibiting mucosal prostaglandin synthesis. Fluid secretion was unaltered by prior treatment of immune rats with a 5-lipoxygenase inhibitor, L-651,392, and only slightly reduced when L-651,392 was used in combination with indomethacin. After a challenge infection, more histamine was released into intestinal loops of immune rats than those of nonimmune rats. Prechallenge treatment of immune rats with indomethacin caused a twofold increase in histamine release. In summary, anaphylaxis-induced fluid secretion in the small intestine is mediated largely by histamine and cyclooxygenase products. This secretion can be lowered by treatment with diphenhydramine and further reduced by diphenhydramine in combination with indomethacin. The paradoxical effects of indomethacin when used alone and in combination with diphenhydramine are explained by the downregulation of histamine release by products of the cyclooxygenase pathway.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
100
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
922-8
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:1705907-Analysis of Variance, pubmed-meshheading:1705907-Anaphylaxis, pubmed-meshheading:1705907-Animals, pubmed-meshheading:1705907-Antigens, Helminth, pubmed-meshheading:1705907-Chlorides, pubmed-meshheading:1705907-Diphenhydramine, pubmed-meshheading:1705907-Drug Synergism, pubmed-meshheading:1705907-Histamine H1 Antagonists, pubmed-meshheading:1705907-Histamine Release, pubmed-meshheading:1705907-Immunization, pubmed-meshheading:1705907-Indomethacin, pubmed-meshheading:1705907-Intestinal Secretions, pubmed-meshheading:1705907-Intestine, Small, pubmed-meshheading:1705907-Lipoxygenase Inhibitors, pubmed-meshheading:1705907-Male, pubmed-meshheading:1705907-Phenothiazines, pubmed-meshheading:1705907-Prostaglandins, pubmed-meshheading:1705907-Rats, pubmed-meshheading:1705907-Rats, Inbred Strains, pubmed-meshheading:1705907-Trichinella, pubmed-meshheading:1705907-Trichinellosis
pubmed:year
1991
pubmed:articleTitle
Inhibition of anaphylaxis-evoked intestinal fluid secretion by the dual application of an H1 antagonist and cyclooxygenase inhibitor.
pubmed:affiliation
Department of Physiology and Cell Biology, University of Texas Medical School, Houston.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.