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rdf:type |
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lifeskim:mentions |
umls-concept:C0017780,
umls-concept:C0041538,
umls-concept:C0086418,
umls-concept:C0524637,
umls-concept:C0678594,
umls-concept:C1514562,
umls-concept:C1527178,
umls-concept:C1823640,
umls-concept:C1880389,
umls-concept:C1883204,
umls-concept:C1883221
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-3
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pubmed:databankReference |
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pubmed:abstractText |
The ESCRT-I and ESCRT-II complexes help sort ubiquitinated proteins into vesicles that accumulate within multivesicular bodies (MVBs). Crystallographic and biochemical analyses reveal that the GLUE domain of the human ESCRT-II EAP45 (also called VPS36) subunit is a split pleckstrin-homology domain that binds ubiquitin along one edge of the beta-sandwich. The structure suggests how human ESCRT-II can couple recognition of ubiquitinated cargoes and endosomal phospholipids during MVB protein sorting.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1545-9993
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1029-30
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pubmed:dateRevised |
2011-4-12
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pubmed:meshHeading |
pubmed-meshheading:17057716-Amino Acid Motifs,
pubmed-meshheading:17057716-Binding Sites,
pubmed-meshheading:17057716-Carrier Proteins,
pubmed-meshheading:17057716-Crystallography, X-Ray,
pubmed-meshheading:17057716-Endosomal Sorting Complexes Required for Transport,
pubmed-meshheading:17057716-Endosomes,
pubmed-meshheading:17057716-Humans,
pubmed-meshheading:17057716-Models, Molecular,
pubmed-meshheading:17057716-Molecular Sequence Data,
pubmed-meshheading:17057716-Protein Folding,
pubmed-meshheading:17057716-Protein Structure, Tertiary,
pubmed-meshheading:17057716-Protein Transport,
pubmed-meshheading:17057716-Recombinant Fusion Proteins,
pubmed-meshheading:17057716-Transport Vesicles,
pubmed-meshheading:17057716-Ubiquitin,
pubmed-meshheading:17057716-Vesicular Transport Proteins
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pubmed:year |
2006
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pubmed:articleTitle |
Structural basis for ubiquitin recognition by the human ESCRT-II EAP45 GLUE domain.
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pubmed:affiliation |
Department of Biochemistry, University of Utah, Salt Lake City, Utah 84112-5650, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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