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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1991-4-9
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pubmed:abstractText |
The hippocampal areas of 34 autopsy specimen brains from aged demented and nondemented subjects were examined using double staining of Bodian and beta protein. In 18 cases (75.5 +/- 7.4 years old), none of the extracellular neurofibrillary tangles (E-NFTs) were immunoreactive with beta protein. In 16 cases (82.9 +/- 5.4 years old), the minority of E-NFTs were immunoreactive with beta-protein antiserum. These beta-immunoreactive E-NFTs frequently appeared in the areas having senile plaques, while they were not observed in the area lacking beta-immunoreactive senile plaques. The ultrastructure of beta-immunoreactive E-NFTs revealed that they consisted of extracellular amyloid fibrils, extracellularly located bundles of paired helical filaments, astroglial processes and degenerating neurites. These findings suggest that the beta immunoreactivity of E-NFTs comes from secondary deposition of amyloid fibrils.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-13907611,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-156000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-1702930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-1703225,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2110847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2407121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2407313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2436433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2441141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2465658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2483105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2671814,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2679112,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2881207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-2963585,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-3059748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-3159021,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-4919693,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-6375662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-7090745,
http://linkedlifedata.com/resource/pubmed/commentcorrection/1705753-7175555
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0002-9440
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
138
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
699-705
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:1705753-Aged,
pubmed-meshheading:1705753-Aged, 80 and over,
pubmed-meshheading:1705753-Alzheimer Disease,
pubmed-meshheading:1705753-Amyloid beta-Peptides,
pubmed-meshheading:1705753-Dementia,
pubmed-meshheading:1705753-Hippocampus,
pubmed-meshheading:1705753-Humans,
pubmed-meshheading:1705753-Immunohistochemistry,
pubmed-meshheading:1705753-Microscopy, Electron,
pubmed-meshheading:1705753-Middle Aged,
pubmed-meshheading:1705753-Neurofibrils,
pubmed-meshheading:1705753-Staining and Labeling
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pubmed:year |
1991
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pubmed:articleTitle |
Secondary deposition of beta amyloid within extracellular neurofibrillary tangles in Alzheimer-type dementia.
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pubmed:affiliation |
College of Medical Care and Technology, Gunma University, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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