Source:http://linkedlifedata.com/resource/pubmed/id/17056551
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
CD4+CD25+FoxP3+ regulatory T cells are decreased in patients infected with HIV and have been shown to be critical in mediating Ag tolerance in the lung. Because a subset of Pneumocystis-infected individuals develop substantial lung injury, which can be modeled in immune reconstituted scid mice, we used mouse models of Pneumocystis carinii to investigate the role of regulatory T cells in opportunistic infection and immune reconstitution. In this study, we show that CD4+CD25+FoxP3+ cells are part of the host response to Pneumocystis in CD4+ T cell-intact mice. Moreover, lung injury and proinflammatory Th1 and Th2 cytokine levels in the bronchoalveolar lavage fluid and lung homogenate were increased following CD4+CD25- immune reconstitution in Pneumocystis-infected SCID mice but not in CD4+CD25+ T cell-reconstituted animals. The ability of CD4+CD25+ T cells to control inflammation and injury during the course of Pneumocystis was confirmed by treatment of wild-type C57BL/6 mice with anti-CD25 mAb. These data show that CD4+CD25+ T cells control pulmonary inflammation and lung injury associated with Pneumocystis infection both in the setting of immune reconstitution as well as new acquisition of infection.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD4,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Forkhead Transcription Factors,
http://linkedlifedata.com/resource/pubmed/chemical/Foxp3 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-2 Receptor alpha Subunit
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6215-26
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17056551-Animals,
pubmed-meshheading:17056551-Antibodies,
pubmed-meshheading:17056551-Antigens, CD4,
pubmed-meshheading:17056551-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17056551-Cytokines,
pubmed-meshheading:17056551-Disease Models, Animal,
pubmed-meshheading:17056551-Forkhead Transcription Factors,
pubmed-meshheading:17056551-Interleukin-2 Receptor alpha Subunit,
pubmed-meshheading:17056551-Lung,
pubmed-meshheading:17056551-Male,
pubmed-meshheading:17056551-Mice,
pubmed-meshheading:17056551-Mice, SCID,
pubmed-meshheading:17056551-Pneumonia, Pneumocystis,
pubmed-meshheading:17056551-T-Lymphocytes, Regulatory,
pubmed-meshheading:17056551-Th1 Cells,
pubmed-meshheading:17056551-Th2 Cells
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pubmed:year |
2006
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pubmed:articleTitle |
Regulatory T cells dampen pulmonary inflammation and lung injury in an animal model of pneumocystis pneumonia.
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pubmed:affiliation |
Department of Pediatrics, and Division of Pulmonary Medicine, Allergy, and Immunology, Children's Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA 15213, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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