| pubmed-article:17056547 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C0521009 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C1819995 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C0007623 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C0020969 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C0277785 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C1419053 | lld:lifeskim |
| pubmed-article:17056547 | lifeskim:mentions | umls-concept:C0243144 | lld:lifeskim |
| pubmed-article:17056547 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:17056547 | pubmed:dateCreated | 2006-10-23 | lld:pubmed |
| pubmed-article:17056547 | pubmed:abstractText | The current model of innate immune recognition of Gram-positive bacteria suggests that the bacterial cell wall interacts with host recognition proteins such as TLRs and Nod proteins. We describe an additional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of bacterial components into host cells. Intravascular choline-containing cell walls bound to endothelial cells and caused rapid lethality in wild-type, Tlr2(-/-), and Nod2(-/-) mice but not in Pafr(-/-) mice. The cell wall exited the vasculature into the heart and brain, accumulating within endothelial cells, cardiomyocytes, and neurons in a PAFr-dependent way. Physiological consequences of the cell wall/PAFr interaction were cell specific, being noninflammatory in endothelial cells and neurons but causing a rapid loss of cardiomyocyte contractility that contributed to death. Thus, PAFr shepherds phosphorylcholine-containing bacterial components such as the cell wall into host cells from where the response ranges from quiescence to severe pathophysiology. | lld:pubmed |
| pubmed-article:17056547 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17056547 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17056547 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:17056547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:17056547 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17056547 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17056547 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17056547 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:TuomanenElain... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:WeberJoerg... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:MurrayPeter... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:FillonSophieS | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:GaberM... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:KaushalDeepak... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:MurtiGopalG | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:RajasekaranSu... | lld:pubmed |
| pubmed-article:17056547 | pubmed:author | pubmed-author:OrihuelaCarlo... | lld:pubmed |
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| pubmed-article:17056547 | pubmed:author | pubmed-author:Benedict-Hami... | lld:pubmed |
| pubmed-article:17056547 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17056547 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:17056547 | pubmed:volume | 177 | lld:pubmed |
| pubmed-article:17056547 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17056547 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17056547 | pubmed:pagination | 6182-91 | lld:pubmed |
| pubmed-article:17056547 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:17056547 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17056547 | pubmed:articleTitle | Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. | lld:pubmed |
| pubmed-article:17056547 | pubmed:affiliation | Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA. | lld:pubmed |
| pubmed-article:17056547 | pubmed:publicationType | Journal Article | lld:pubmed |
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