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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
The current model of innate immune recognition of Gram-positive bacteria suggests that the bacterial cell wall interacts with host recognition proteins such as TLRs and Nod proteins. We describe an additional recognition system mediated by the platelet-activating factor receptor (PAFr) and directed to the pathogen-associated molecular pattern phosphorylcholine that results in the uptake of bacterial components into host cells. Intravascular choline-containing cell walls bound to endothelial cells and caused rapid lethality in wild-type, Tlr2(-/-), and Nod2(-/-) mice but not in Pafr(-/-) mice. The cell wall exited the vasculature into the heart and brain, accumulating within endothelial cells, cardiomyocytes, and neurons in a PAFr-dependent way. Physiological consequences of the cell wall/PAFr interaction were cell specific, being noninflammatory in endothelial cells and neurons but causing a rapid loss of cardiomyocyte contractility that contributed to death. Thus, PAFr shepherds phosphorylcholine-containing bacterial components such as the cell wall into host cells from where the response ranges from quiescence to severe pathophysiology.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Card15 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Nod2 Signaling Adaptor Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphorylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Platelet Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, G-Protein-Coupled,
http://linkedlifedata.com/resource/pubmed/chemical/Tlr2 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Toll-Like Receptor 2,
http://linkedlifedata.com/resource/pubmed/chemical/platelet activating factor receptor
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:Benedict-HamiltonHeatherH,
pubmed-author:El KasmiKarim CKC,
pubmed-author:FillonSophieS,
pubmed-author:GaberM WaleedMW,
pubmed-author:KaushalDeepakD,
pubmed-author:MurrayPeter JPJ,
pubmed-author:MurtiGopalG,
pubmed-author:OrihuelaCarlos JCJ,
pubmed-author:RadinJana NJN,
pubmed-author:RajasekaranSurenderS,
pubmed-author:SoulisKonstantinosK,
pubmed-author:TuomanenElaine IEI,
pubmed-author:WeberJoerg RJR
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6182-91
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17056547-Animals,
pubmed-meshheading:17056547-Cell Wall,
pubmed-meshheading:17056547-Endothelium, Vascular,
pubmed-meshheading:17056547-Gram-Positive Bacteria,
pubmed-meshheading:17056547-Immunity, Innate,
pubmed-meshheading:17056547-Mice,
pubmed-meshheading:17056547-Mice, Mutant Strains,
pubmed-meshheading:17056547-Myocytes, Cardiac,
pubmed-meshheading:17056547-Neurons,
pubmed-meshheading:17056547-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:17056547-Phosphorylcholine,
pubmed-meshheading:17056547-Platelet Membrane Glycoproteins,
pubmed-meshheading:17056547-Pneumococcal Infections,
pubmed-meshheading:17056547-Rats,
pubmed-meshheading:17056547-Receptors, G-Protein-Coupled,
pubmed-meshheading:17056547-Streptococcus pneumoniae,
pubmed-meshheading:17056547-Toll-Like Receptor 2
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pubmed:year |
2006
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pubmed:articleTitle |
Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.
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pubmed:affiliation |
Department of Infectious Diseases, St. Jude Children's Research Hospital, 332 North Lauderdale Street, Memphis, TN 38105, USA.
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pubmed:publicationType |
Journal Article
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