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rdf:type |
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lifeskim:mentions |
umls-concept:C0011155,
umls-concept:C0024429,
umls-concept:C0152060,
umls-concept:C0205154,
umls-concept:C0312359,
umls-concept:C0458827,
umls-concept:C0591833,
umls-concept:C0700624,
umls-concept:C0871261,
umls-concept:C1306235,
umls-concept:C1334507,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
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pubmed:issue |
9
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
Increased levels of macrophage migration inhibitory factor (MIF) in serum, sputum, and bronchioalveolar lavage fluid (BALF) from asthmatic patients and time/dose-dependent expression of MIF in eosinophils in response to phorbol myristate acetate suggest the participation of MIF in airway inflammation. In this study, we examined inflammation in OVA-sensitized mouse lungs in wild-type and MIF-deficient mice (MIF(-/-)). We report increased MIF in the lung and BALF of sensitized wild-type mice. MIF(-/-) mice demonstrated significant reductions in serum IgE and alveolar inflammatory cell recruitment. Reduced Th1/Th2 cytokines and chemokines also were detected in serum or BALF from MIF(-/-) mice. Importantly, alveolar macrophages and mast cells, but not dendritic cells or splenocytes, from MIF(-/-) mice demonstrated impaired CD4+ T cell activation, and the reconstitution of wild-type mast cells in MIF(-/-) mice restored the phenotype of OVA-induced airway inflammation, revealing a novel and essential role of mast cell-derived MIF in experimentally induced airway allergic diseases.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0022-1767
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pubmed:author |
pubmed-author:BucalaRichardR,
pubmed-author:ChapmanHarold AHA,
pubmed-author:DavidJohn RJR,
pubmed-author:FinnPatricia WPW,
pubmed-author:HuangXiaozhuX,
pubmed-author:KitamotoShiroS,
pubmed-author:LengLinL,
pubmed-author:RieseRichardR,
pubmed-author:ShiGuo-PingGP,
pubmed-author:SunJiusongJ,
pubmed-author:WangBingB,
pubmed-author:WoltersPaul JPJ,
pubmed-author:YangMinM
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
177
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
|
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pubmed:pagination |
5779-84
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17056501-Animals,
pubmed-meshheading:17056501-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:17056501-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17056501-Chemokines,
pubmed-meshheading:17056501-Cytokines,
pubmed-meshheading:17056501-Dendritic Cells,
pubmed-meshheading:17056501-Hypersensitivity,
pubmed-meshheading:17056501-Immunoglobulin E,
pubmed-meshheading:17056501-Lung,
pubmed-meshheading:17056501-Lymphocyte Activation,
pubmed-meshheading:17056501-Macrophage Migration-Inhibitory Factors,
pubmed-meshheading:17056501-Macrophages, Alveolar,
pubmed-meshheading:17056501-Mast Cells,
pubmed-meshheading:17056501-Mice,
pubmed-meshheading:17056501-Mice, Mutant Strains,
pubmed-meshheading:17056501-Ovalbumin,
pubmed-meshheading:17056501-Pneumonia,
pubmed-meshheading:17056501-Th1 Cells,
pubmed-meshheading:17056501-Th2 Cells
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pubmed:year |
2006
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pubmed:articleTitle |
Cutting edge: Deficiency of macrophage migration inhibitory factor impairs murine airway allergic responses.
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pubmed:affiliation |
Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 77th Avenue Louis Pasteur, Boston, MA 02115, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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