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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
2006-11-27
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pubmed:abstractText |
ERB-041 (2-(3-Fluoro-4-hydroxyphenyl)-7-vinyl-1,3 benzoxazol-5-ol) is a selective estrogen receptor-beta agonist with activity in rodent models of rheumatoid arthritis and endometriosis. Clinical trials for these diseases are underway: however, the role of estrogen receptor-beta in modulating pain associated with inflammation remains unknown. These studies demonstrate that acutely administered ERB-041 is anti-hyperalgesic in preclinical models of chemical-induced and acute inflammatory pain, thus suggesting that ERB-041 may be useful for modulating pain associated with some types of inflammation.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0014-2999
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:day |
28
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pubmed:volume |
553
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
146-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17056036-Animals,
pubmed-meshheading:17056036-Dose-Response Relationship, Drug,
pubmed-meshheading:17056036-Estradiol,
pubmed-meshheading:17056036-Estrogen Receptor beta,
pubmed-meshheading:17056036-Hot Temperature,
pubmed-meshheading:17056036-Hyperalgesia,
pubmed-meshheading:17056036-Inflammation,
pubmed-meshheading:17056036-Male,
pubmed-meshheading:17056036-Oxazoles,
pubmed-meshheading:17056036-Pain,
pubmed-meshheading:17056036-Rats,
pubmed-meshheading:17056036-Rats, Sprague-Dawley
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pubmed:year |
2006
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pubmed:articleTitle |
An estrogen receptor-beta agonist is active in models of inflammatory and chemical-induced pain.
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pubmed:affiliation |
Neuroscience Discovery Research, Wyeth Research, Princeton, NJ 08543, United States.
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pubmed:publicationType |
Journal Article
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