Source:http://linkedlifedata.com/resource/pubmed/id/17055731
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
2006-11-20
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| pubmed:abstractText |
A new series of 1beta-methyl carbapenems, possessing a 7-substituted imidazo[5,1-b]thiazol-2-yl group directly attached to the C-2 position of the carbapenem nucleus, was synthesized and evaluated for antibacterial activity. These compounds showed potent activities against Gram-positive bacteria, in particular methicillin-resistant Staphylococcus aureus (MRSA) and penicillin-resistant Streptococcus pneumoniae (PRSP). They also exhibited potent activity against beta-lactamase-negative ampicillin-resistant Haemophilus influenzae (BLNAR).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
|
| pubmed:issn |
0968-0896
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
15
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
392-402
|
| pubmed:meshHeading |
pubmed-meshheading:17055731-Anti-Bacterial Agents,
pubmed-meshheading:17055731-Carbapenems,
pubmed-meshheading:17055731-Haemophilus influenzae,
pubmed-meshheading:17055731-Microbial Sensitivity Tests,
pubmed-meshheading:17055731-Molecular Conformation,
pubmed-meshheading:17055731-Pyridinium Compounds,
pubmed-meshheading:17055731-Staphylococcus aureus,
pubmed-meshheading:17055731-Stereoisomerism,
pubmed-meshheading:17055731-Streptococcus pneumoniae,
pubmed-meshheading:17055731-Structure-Activity Relationship
|
| pubmed:year |
2007
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| pubmed:articleTitle |
Synthesis and SAR study of novel 7-(pyridinium-3-yl)-carbonyl imidazo[5,1-b]thiazol-2-yl carbapenems.
|
| pubmed:affiliation |
Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd, 760 Morooka-cho, Kohoku-ku, Yokohama 222-8567, Japan. takahisa_maruyama@meiji.co.jp
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| pubmed:publicationType |
Journal Article
|