rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
2006-10-23
|
pubmed:abstractText |
RNA interference (RNAi) refers to the phenomenon of sequence-specific degradation of homologous mRNA induced by double-stranded RNA. It has been successfully utilized to down-regulate endogenous gene expression or suppress the replication of various pathogens in mammalian cells. In this study, the effect of vector-based small interfering RNA (siRNA) promoted by pSilencer2.0-U6 inhibit hepatitis B virus (HBV) replication in cell culture was evaluated.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B e Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents,
http://linkedlifedata.com/resource/pubmed/chemical/Lipids,
http://linkedlifedata.com/resource/pubmed/chemical/Lipofectamine,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral
|
pubmed:status |
MEDLINE
|
pubmed:issn |
1443-9611
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
7
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
230-6
|
pubmed:meshHeading |
pubmed-meshheading:17054586-Cell Line,
pubmed-meshheading:17054586-DNA, Viral,
pubmed-meshheading:17054586-Gene Expression Regulation, Viral,
pubmed-meshheading:17054586-Genetic Vectors,
pubmed-meshheading:17054586-Hepatitis B Surface Antigens,
pubmed-meshheading:17054586-Hepatitis B e Antigens,
pubmed-meshheading:17054586-Hepatitis B virus,
pubmed-meshheading:17054586-Humans,
pubmed-meshheading:17054586-Indicators and Reagents,
pubmed-meshheading:17054586-Lipids,
pubmed-meshheading:17054586-RNA, Small Interfering,
pubmed-meshheading:17054586-RNA, Viral,
pubmed-meshheading:17054586-RNA Interference,
pubmed-meshheading:17054586-Transfection,
pubmed-meshheading:17054586-Virus Replication
|
pubmed:year |
2006
|
pubmed:articleTitle |
RNA interference inhibits hepatitis B virus gene expression and replication in HepG2-N10 cells.
|
pubmed:affiliation |
Department of Gastroenterology, Zhongshan Hospital, Xiamen University, Xiamen, Fujian Province, China. jianlinr@msn.com
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|