Source:http://linkedlifedata.com/resource/pubmed/id/17053564
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
2007-2-21
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| pubmed:abstractText |
Aseptic loosening induced by wear particles from the polyethylene liner is likely the most common cause of long-term total hip arthroplasty failure. We developed a novel hip polyethylene liner with the surface graft of a biocompatible phospholipid polymer, 2-methacryloyloxyethyl phosphorylcholine (MPC), and previously reported the grafting decreased the short-term production of wear particles and the subsequent bone resorptive responses. For clinical application, we investigated the stability of the 2-methacryloyloxyethyl phosphorylcholine grafting during sterilization and the wear resistance of the sterilized liner during longer loading comparable to clinical usage. Radiographic spectroscopy confirmed the stability of the 2-methacryloyloxyethyl phosphorylcholine polymer on the liner surface after the gamma irradiation. We used a hip wear simulator up to 1 x 10(7) cycles to test sterilized cross-linked polyethylene liners with and without 2-methacryloyloxyethyl phosphorylcholine grafting. The 2-methacryloyloxyethyl phosphorylcholine grafting markedly decreased the friction, the production of wear particles, and the wear of the liner surface. These data suggest a marked improvement in the wear resistance of the polyethylene liner by the 2-methacryloyloxyethyl phosphorylcholine grafting for clinically relevant periods after sterilization, indicating 2-methacryloyloxyethyl phosphorylcholine grafting is a promising technology for extending longevity of artificial hips.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
AIM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
0009-921X
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
453
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
58-63
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| pubmed:meshHeading |
pubmed-meshheading:17053564-Gamma Rays,
pubmed-meshheading:17053564-Hip Prosthesis,
pubmed-meshheading:17053564-Materials Testing,
pubmed-meshheading:17053564-Methacrylates,
pubmed-meshheading:17053564-Phosphorylcholine,
pubmed-meshheading:17053564-Polyethylene,
pubmed-meshheading:17053564-Prosthesis Failure,
pubmed-meshheading:17053564-Sterilization,
pubmed-meshheading:17053564-Stress, Mechanical
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| pubmed:year |
2006
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| pubmed:articleTitle |
2006 Frank Stinchfield Award: grafting of biocompatible polymer for longevity of artificial hip joints.
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| pubmed:affiliation |
Department of Sensory and Motor System Medicine, Faculty of Medicine, The University of Tokyo, Hongo 7-3-1, Bunkyo, Tokyo 113-0033, Japan. moro-ort@h.u-tokyo.ac.jp
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| pubmed:publicationType |
Journal Article
|