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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2006-12-4
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pubmed:abstractText |
Ordered assembly of scaffold proteins Carma1-Bcl10-Malt1 determines NF-kappaB activation following T cell receptor (TCR) engagement. Carma1-Bcl10 interaction and the signaling pathway are controlled by Carma1 phosphorylation, which are induced by PKCtheta and Ca(2+)/calmodulin-dependent protein kinase II (CaMKII). In addition to Carma1 phosphorylation, previous studies have demonstrated that Bcl10 is phosphorylated in the C-terminal Ser/Thr rich region following TCR engagement. However the kinases that phosphorylate Bcl10 are incompletely understood. Here we show that CaMKII phosphorylates Bcl10 on Ser138. Furthermore, a CaMKII inhibitor, KN93, and CaMKII siRNA substantially reduce Bcl10 phosphorylation induced by phorbol myristate acetate/ionomycin. S138A mutation prolongs Bcl10-induced NF-kappaB activation, suggesting that Bcl10 phosphorylation is involved in attenuation of NF-kappaB activation. These findings suggest that CaMKII modulates NF-kappaB activation via phosphorylating Bcl10 as well as Carma1.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adaptor Proteins, Signal Transducing,
http://linkedlifedata.com/resource/pubmed/chemical/Apoptosis Regulatory Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/BCL10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Benzylamines,
http://linkedlifedata.com/resource/pubmed/chemical/CARD Signaling Adaptor Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/CARD11 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium-Calmodulin-Dependent...,
http://linkedlifedata.com/resource/pubmed/chemical/Carcinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Caspases,
http://linkedlifedata.com/resource/pubmed/chemical/Guanylate Cyclase,
http://linkedlifedata.com/resource/pubmed/chemical/Ionomycin,
http://linkedlifedata.com/resource/pubmed/chemical/Ionophores,
http://linkedlifedata.com/resource/pubmed/chemical/Isoenzymes,
http://linkedlifedata.com/resource/pubmed/chemical/KN 93,
http://linkedlifedata.com/resource/pubmed/chemical/MALT1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRKCQ protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase C,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Kinase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Small Interfering,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell,
http://linkedlifedata.com/resource/pubmed/chemical/Serine,
http://linkedlifedata.com/resource/pubmed/chemical/Sulfonamides,
http://linkedlifedata.com/resource/pubmed/chemical/Tetradecanoylphorbol Acetate
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0161-5890
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
44
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2095-100
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pubmed:dateRevised |
2011-10-31
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pubmed:meshHeading |
pubmed-meshheading:17052756-Adaptor Proteins, Signal Transducing,
pubmed-meshheading:17052756-Apoptosis Regulatory Proteins,
pubmed-meshheading:17052756-Benzylamines,
pubmed-meshheading:17052756-CARD Signaling Adaptor Proteins,
pubmed-meshheading:17052756-Calcium-Calmodulin-Dependent Protein Kinase Type 2,
pubmed-meshheading:17052756-Calcium-Calmodulin-Dependent Protein Kinases,
pubmed-meshheading:17052756-Carcinogens,
pubmed-meshheading:17052756-Caspases,
pubmed-meshheading:17052756-Guanylate Cyclase,
pubmed-meshheading:17052756-Humans,
pubmed-meshheading:17052756-Ionomycin,
pubmed-meshheading:17052756-Ionophores,
pubmed-meshheading:17052756-Isoenzymes,
pubmed-meshheading:17052756-Jurkat Cells,
pubmed-meshheading:17052756-Mutation, Missense,
pubmed-meshheading:17052756-NF-kappa B,
pubmed-meshheading:17052756-Neoplasm Proteins,
pubmed-meshheading:17052756-Phosphorylation,
pubmed-meshheading:17052756-Protein Kinase C,
pubmed-meshheading:17052756-Protein Kinase Inhibitors,
pubmed-meshheading:17052756-Protein Processing, Post-Translational,
pubmed-meshheading:17052756-RNA, Small Interfering,
pubmed-meshheading:17052756-Receptors, Antigen, T-Cell,
pubmed-meshheading:17052756-Serine,
pubmed-meshheading:17052756-Signal Transduction,
pubmed-meshheading:17052756-Sulfonamides,
pubmed-meshheading:17052756-T-Lymphocytes,
pubmed-meshheading:17052756-Tetradecanoylphorbol Acetate
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pubmed:year |
2007
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pubmed:articleTitle |
Bcl10 is phosphorylated on Ser138 by Ca2+/calmodulin-dependent protein kinase II.
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pubmed:affiliation |
Molecular Biology and Pathogenesis of Gastroenterology, Nagoya University School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan. kio@med.nagoya-u.ac.jp
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pubmed:publicationType |
Journal Article
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