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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
An efficient microwave-assisted synthesis of new (Z)-5-arylidenerhodanines under solvent-free conditions is described and their in vitro antifungal activity was evaluated following the CLSI (formerly NCCLS) guidelines against a panel of both standardized and clinical opportunistic pathogenic fungi. An analysis of the structure-activity relationship (SAR) along with computational studies showed that the most active compounds (F- and CF(3)-substituted rhodanines) possess high logP values and low polarizability. Mechanism-based assays suggest that active compounds neither would bind to ergosterol nor would produce a damage to the fungal membrane.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:AboníaRodrigoR,
pubmed-author:DelgadoPaulaP,
pubmed-author:EnrizRicardo DRD,
pubmed-author:GaribottoFrancisco MFM,
pubmed-author:InsuastyBraulioB,
pubmed-author:JuárezSabinaS,
pubmed-author:NoguerasManuelM,
pubmed-author:QuirogaJairoJ,
pubmed-author:RoderoLauraL,
pubmed-author:SortinoMaximilianoM,
pubmed-author:ZacchinoSusana ASA
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
484-94
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pubmed:meshHeading |
pubmed-meshheading:17049255-Antifungal Agents,
pubmed-meshheading:17049255-Computer Simulation,
pubmed-meshheading:17049255-Drug Design,
pubmed-meshheading:17049255-Microbial Sensitivity Tests,
pubmed-meshheading:17049255-Microwaves,
pubmed-meshheading:17049255-Mitosporic Fungi,
pubmed-meshheading:17049255-Molecular Structure,
pubmed-meshheading:17049255-Rhodanine,
pubmed-meshheading:17049255-Sensitivity and Specificity,
pubmed-meshheading:17049255-Stereoisomerism,
pubmed-meshheading:17049255-Structure-Activity Relationship,
pubmed-meshheading:17049255-Yeasts
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and antifungal activity of (Z)-5-arylidenerhodanines.
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pubmed:affiliation |
Farmacognosia, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, (2000), Rosario, Argentina.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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