Source:http://linkedlifedata.com/resource/pubmed/id/17049254
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
One hundred seven 2-arylquinolin-4-amines were assayed in vitro for inhibition of the immunostimulatory effect of oligodeoxynucleotides containing a CpG-motif. The compounds are functionalized with various basic and non-basic groups at the aryl moiety and at the amino substituent of the quinolin-4-amine, and some of them contain an additional substituent at position 6 or 7 of the quinoline. Activities of these antagonists, expressed as EC(50) values, range from 0.2 to 200nM. A statistically significant structure-activity correlation was obtained for the Fujita-Ban variant of the classical Free-Wilson analysis. The CoMFA results derived from several models consistently indicate that electrostatic interactions of the molecules with a biological receptor contribute to biological activities to a greater extent than steric effects.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-32
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pubmed:meshHeading |
pubmed-meshheading:17049254-Adjuvants, Immunologic,
pubmed-meshheading:17049254-Aminoquinolines,
pubmed-meshheading:17049254-Animals,
pubmed-meshheading:17049254-Binding Sites,
pubmed-meshheading:17049254-Cell Line, Tumor,
pubmed-meshheading:17049254-Computer Simulation,
pubmed-meshheading:17049254-Drug Screening Assays, Antitumor,
pubmed-meshheading:17049254-Lymphoma, B-Cell,
pubmed-meshheading:17049254-Mice,
pubmed-meshheading:17049254-Models, Molecular,
pubmed-meshheading:17049254-Molecular Structure,
pubmed-meshheading:17049254-Oligodeoxyribonucleotides,
pubmed-meshheading:17049254-Quantitative Structure-Activity Relationship,
pubmed-meshheading:17049254-Stereoisomerism,
pubmed-meshheading:17049254-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Fujita-Ban QSAR analysis and CoMFA study of quinoline antagonists of immunostimulatory CpG-oligodeoxynucleotides.
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pubmed:affiliation |
Department of Chemistry, Georgia State University, Atlanta, GA 30302, USA.
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pubmed:publicationType |
Journal Article
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