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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
An original series of 4-substituted pyrrolo[1,2-a]quinoxaline derivatives, new structural analogues of Galipea species quinoline alkaloids, was synthesized from various substituted 2-nitroanilines via multistep heterocyclizations and tested for in vitro antiparasitic activity upon Leishmania amazonensis and Leishmania infantum strains. Structure-activity relationships enlighten the importance of the 4-substituted alkenyl side chain on the pyrrolo[1,2-a]quinoxaline moiety to modulate the antileishmanial activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:DesplatVanessaV,
pubmed-author:DufaureBenoitB,
pubmed-author:ForfarIsabelleI,
pubmed-author:GuillonJeanJ,
pubmed-author:HaumontGilbertG,
pubmed-author:JarryChristianC,
pubmed-author:LégerJean-MichelJM,
pubmed-author:Mamani-MatsudaMariaM,
pubmed-author:MassipStéphaneS,
pubmed-author:MossalayiDjavadD,
pubmed-author:SaliègeMarionM,
pubmed-author:TabourierAnaisA,
pubmed-author:ThiolatDenisD
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-210
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17049253-Animals,
pubmed-meshheading:17049253-Antiprotozoal Agents,
pubmed-meshheading:17049253-Crystallography, X-Ray,
pubmed-meshheading:17049253-Humans,
pubmed-meshheading:17049253-Hydrophobic and Hydrophilic Interactions,
pubmed-meshheading:17049253-Leishmania,
pubmed-meshheading:17049253-Leukocytes, Mononuclear,
pubmed-meshheading:17049253-Models, Molecular,
pubmed-meshheading:17049253-Molecular Structure,
pubmed-meshheading:17049253-Parasitic Sensitivity Tests,
pubmed-meshheading:17049253-Quinoxalines,
pubmed-meshheading:17049253-Stereoisomerism,
pubmed-meshheading:17049253-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis, analytical behaviour and biological evaluation of new 4-substituted pyrrolo[1,2-a]quinoxalines as antileishmanial agents.
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pubmed:affiliation |
EA 2962-Pharmacochimie, UFR des Sciences Pharmaceutiques, Université Victor Segalen Bordeaux 2, 146 rue Léo Saignat, 33076 Bordeaux Cedex, France. Jean.Guillon@chimphys.u-bordeaux2.fr
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pubmed:publicationType |
Journal Article
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