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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
Novel 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides were prepared as a new class of antitumor agents and showed significant antitumor activities against NCI-H 460, HCT 116, A 431, CCRF-HSB-2, andKB cell lines. In vivo investigation, 2-deoxo-10-methyl-2-phenyl-5-deazaflavin exhibited the effective antitumor activity against A 431 human adenocarcinoma cells transplanted subcutaneously into nude mouse. Furthermore, AutoDock study has been done by binding of the flavin analogs into PTK pp60(c-src), where a good correlation between their IC(50) and AutoDock binding free energy was exhibited. In particular, 2-deoxo-2-phenylflavin-5-oxides exhibited the highest potential binding affinity within the binding pocket of PTK.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
pubmed-author:AkahoEiichiE,
pubmed-author:AliHamed IHI,
pubmed-author:AshidaNoriyukiN,
pubmed-author:HayakawaHiroyukiH,
pubmed-author:IkeyaHisaoH,
pubmed-author:KambaraHirotoH,
pubmed-author:KawashimaYutakaY,
pubmed-author:MiuraShinjiS,
pubmed-author:NagamatsuTomohisaT,
pubmed-author:TomitaKeiichiroK,
pubmed-author:YamagishiTakehiroT,
pubmed-author:YonedaFumioF
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
242-56
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pubmed:meshHeading |
pubmed-meshheading:17049252-Antineoplastic Agents,
pubmed-meshheading:17049252-Binding Sites,
pubmed-meshheading:17049252-Cell Line, Tumor,
pubmed-meshheading:17049252-Cell Proliferation,
pubmed-meshheading:17049252-Computer Simulation,
pubmed-meshheading:17049252-Drug Design,
pubmed-meshheading:17049252-Drug Screening Assays, Antitumor,
pubmed-meshheading:17049252-Flavins,
pubmed-meshheading:17049252-Humans,
pubmed-meshheading:17049252-Ligands,
pubmed-meshheading:17049252-Models, Molecular,
pubmed-meshheading:17049252-Molecular Structure,
pubmed-meshheading:17049252-Oxides,
pubmed-meshheading:17049252-Protein Conformation,
pubmed-meshheading:17049252-Protein Structure, Tertiary,
pubmed-meshheading:17049252-Stereoisomerism,
pubmed-meshheading:17049252-Structure-Activity Relationship,
pubmed-meshheading:17049252-Time Factors
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pubmed:year |
2007
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pubmed:articleTitle |
Antitumor studies. Part 1: design, synthesis, antitumor activity, and AutoDock study of 2-deoxo-2-phenyl-5-deazaflavins and 2-deoxo-2-phenylflavin-5-oxides as a new class of antitumor agents.
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pubmed:affiliation |
Division of Pharmaceutical Sciences, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University 1-1-1, Tsushima-naka, Okayama 700-8530, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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