Linked Life Data

17049197

Source:http://linkedlifedata.com/resource/pubmed/id/17049197

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-2-5
pubmed:abstractText
A selective and sensitive high-performance liquid chromatography-electrospray ionization mass spectrometry method has been developed for the determination of sodium ferulate in human plasma. The sample preparation was a liquid-liquid extraction and chromatographic separation was achieved with an Agilent ZORBAX SB-C(18) (3.5 microm, 100 mm x 3.0 mm) column, using a mobile phase of methanol-0.05% acetic acid 40:60 (v/v). Standard curves were linear (r(2)=0.9982) over the concentration range of 0.007-4.63 nM/ml and had acceptable accuracy and precision. The within- and between-batch precisions were within 12% relative standard deviation. The lower limit of quantification (LLOQ) was 0.007 nM/ml. The validated HPLC-ESI-MS method has been used successfully to study sodium ferulate pharmacokinetics, bioavailability and bioequivalence in 20 healthy volunteers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0731-7085
pubmed:author
pubmed:issnType
Print
pubmed:day
19
pubmed:volume
43
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
945-50
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
High-performance liquid chromatography-electrospray ionization mass spectrometry determination of sodium ferulate in human plasma.
pubmed:affiliation
Key Laboratory of Drug Quality Control and Pharmacovigilance (China Pharmaceutical University), Ministry of Education, China.
pubmed:publicationType
Journal Article, Randomized Controlled Trial