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pubmed-article:17048977pubmed:abstractTextThe objectives of the present study were: (i) to analyse the population pharmacokinetics of sirolimus in renal transplant recipients co-administered mycophenolate mofetil, but no calcineurin inhibitor over the first 3 months post-transplantation and study the influence of different potential covariates, including genetic polymorphisms of cytochrome P450 (CYP) metabolic enzymes and active transporters, on pharmacokinetic parameters; and (ii) to develop a Bayesian estimator able to reliably estimate the individual pharmacokinetic parameters and exposure indices in this population.lld:pubmed
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pubmed-article:17048977pubmed:articleTitleSirolimus population pharmacokinetic/pharmacogenetic analysis and bayesian modelling in kidney transplant recipients.lld:pubmed
pubmed-article:17048977pubmed:affiliationLaboratory of Pharmacology, Faculty of Medicine, Limoges University, Limoges, France.lld:pubmed
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