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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-10-19
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pubmed:abstractText |
The objectives of the present study were: (i) to analyse the population pharmacokinetics of sirolimus in renal transplant recipients co-administered mycophenolate mofetil, but no calcineurin inhibitor over the first 3 months post-transplantation and study the influence of different potential covariates, including genetic polymorphisms of cytochrome P450 (CYP) metabolic enzymes and active transporters, on pharmacokinetic parameters; and (ii) to develop a Bayesian estimator able to reliably estimate the individual pharmacokinetic parameters and exposure indices in this population.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0312-5963
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
45
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1135-48
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17048977-Adult,
pubmed-meshheading:17048977-Aged,
pubmed-meshheading:17048977-Area Under Curve,
pubmed-meshheading:17048977-Bayes Theorem,
pubmed-meshheading:17048977-Clinical Trials as Topic,
pubmed-meshheading:17048977-Cytochrome P-450 CYP3A,
pubmed-meshheading:17048977-Cytochrome P-450 Enzyme System,
pubmed-meshheading:17048977-Drug Therapy, Combination,
pubmed-meshheading:17048977-Female,
pubmed-meshheading:17048977-Genotype,
pubmed-meshheading:17048977-Graft Rejection,
pubmed-meshheading:17048977-Humans,
pubmed-meshheading:17048977-Immunosuppressive Agents,
pubmed-meshheading:17048977-Kidney Transplantation,
pubmed-meshheading:17048977-Liver,
pubmed-meshheading:17048977-Male,
pubmed-meshheading:17048977-Middle Aged,
pubmed-meshheading:17048977-Models, Biological,
pubmed-meshheading:17048977-Mycophenolic Acid,
pubmed-meshheading:17048977-Polymorphism, Genetic,
pubmed-meshheading:17048977-Predictive Value of Tests,
pubmed-meshheading:17048977-Prospective Studies,
pubmed-meshheading:17048977-Reproducibility of Results,
pubmed-meshheading:17048977-Retrospective Studies,
pubmed-meshheading:17048977-Sirolimus,
pubmed-meshheading:17048977-Time Factors
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pubmed:year |
2006
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pubmed:articleTitle |
Sirolimus population pharmacokinetic/pharmacogenetic analysis and bayesian modelling in kidney transplant recipients.
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pubmed:affiliation |
Laboratory of Pharmacology, Faculty of Medicine, Limoges University, Limoges, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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