Linked Life Data

1704837

Source:http://linkedlifedata.com/resource/pubmed/id/1704837

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-3-28
pubmed:abstractText
The effects of the benzodiazepine clonazepam (a drug used as anticonvulsant) on event-related brain potentials were investigated in healthy human subjects. Thirty-six male student volunteers (mean age 30 years) received clonazepam or a placebo in a double-blind setting. VEPs (visual evoked potentials) were obtained from the standard checkerboard reversal procedure; AEPs (auditory evoked potentials) and slow cortical potentials (CNV) were measured during a 2-stimulus reaction time paradigm, in which the quality of the acoustic S1 signalled whether the acoustic S2 would follow after 2 sec or after 6 sec. Each S2 requested a speeded button press. Compared to placebo, clonazepam significantly reduced P100 amplitude of the VEP and the amplitudes of the AEP components N1 and P3. On the other hand, clonazepam boosted the development of a distinct N2 which was not apparent in placebo subjects. The CNV was significantly reduced and reaction time increased under clonazepam compared to placebo. Specific versus non-specific damping effects of the benzodiazepine are discussed, comparing the present result with the pattern of ERP effects of the anticonvulsant carbamazepine that had been obtained using the same experimental paradigms.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
78
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
142-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Effects of the anticonvulsant benzodiazepine clonazepam on event-related brain potentials in humans.
pubmed:affiliation
Department of Clinical and Physiological Psychology, Eberhard-Karls-Universität, Tübingen, F.R.G.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Controlled Clinical Trial, Research Support, Non-U.S. Gov't