Linked Life Data

17048123

Source:http://linkedlifedata.com/resource/pubmed/id/17048123

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2007-9-3
pubmed:abstractText
Optically pure (S)-3-p-hydroxyphenyllactic acid derivatives are important intermediates of peroxisome proliferator-activated receptor alpha/gamma dual agonists and heteropeptides. Many efforts have been made for synthesis of those intermediates, but there exist some flaws yet. We observed that dielectric constants of organic solvents drastically affected diazotization of O-benzyl-L-tyrosine. Optically pure (S)-3-p-benzyloxyphenyllactic acid was obtained by simple recrystallization when DMF or DMSO of higher dielectric constant was used as a co-solvent in diazotization of O-benzyl-L-tyrosine. It was easily turned into various optically pure (S)-3-p-hydroxyphenyllactic acid derivatives.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
1438-2199
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
33
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
537-41
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Facile synthesis of optically pure (S)-3-p-hydroxyphenyllactic acid derivatives.
pubmed:affiliation
Key Laboratory for Chemical Biology of the Province of Fujian, Department of Chemistry, Xiamen University, Xiamen, China. qlzeng@cdut.edu.cn
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't