Linked Life Data

17047453

Source:http://linkedlifedata.com/resource/pubmed/id/17047453

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
16
pubmed:dateCreated
2006-10-18
pubmed:abstractText
Apolipoprotein E-epsilon4 is the main known genetic risk factor for Alzheimer's disease. Functional abnormalities in the parietal cortex have been reported for Alzheimer's disease patients and also for those at risk. Hence, a critical question is whether measurements of parietal cortex integrity may predict negative outcome among at-risk persons. We studied nondemented apolipoprotein E-epsilon4 carriers and found a significant relationship between parietal blood-oxygen-level-dependent functional magnetic resonance imaging response during a word categorization task and subsequent episodic memory performance. Thus, the results show that parietal cortex alterations predict memory decline in nondemented apolipoprotein E-epsilon4 carriers, and hence likely progression to Alzheimer's disease.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0959-4965
pubmed:author
pubmed:issnType
Print
pubmed:day
6
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1683-6
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Parietal cortex activation predicts memory decline in apolipoprotein E-epsilon4 carriers.
pubmed:affiliation
Department of Clinical Neuroscience, Karolinska Institute, MR Research Center, Karolinska Hospital, and Department of Psychology, Stockholm University, Stockholm, Sweden. Johanna.lind@ki.se
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't