| pubmed-article:17046818 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C0229951 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C0025148 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C0001629 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1550278 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C0905070 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C0004368 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:17046818 | lifeskim:mentions | umls-concept:C1998811 | lld:lifeskim |
| pubmed-article:17046818 | pubmed:issue | 50 | lld:pubmed |
| pubmed-article:17046818 | pubmed:dateCreated | 2006-12-12 | lld:pubmed |
| pubmed-article:17046818 | pubmed:abstractText | Medullary thymic epithelial cells function as antigen-presenting cells in negative selection of self-reactive T cell clones, a process essential for the establishment of central self-tolerance. These cells mirror peripheral tissues through promiscuous expression of a diverse set of tissue-restricted self-antigens. The genes and signaling pathways that regulate the development of medullary thymic epithelial cells are not fully understood. Here we show that mice deficient in NF-kappaB2, a member of the NF-kappaB family, display a marked reduction in the number of mature medullary thymic epithelial cells that express CD80 and bind the lectin Ulex europaeus agglutinin-1, leading to a significant decrease in the extent of promiscuous gene expression in the thymus of NF-kappaB2(-/-) mice. Moreover, NF-kappaB2(-/-) mice manifest autoimmunity characterized by multiorgan infiltration of activated T cells and high levels of autoantibodies to multiple organs. A subpopulation of the mice also develops immune complex glomerulonephritis. These findings identify a physiological function of NF-kappaB2 in the development of medullary thymic epithelial cells and, thus, the control of self-tolerance induction. | lld:pubmed |
| pubmed-article:17046818 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17046818 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17046818 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17046818 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17046818 | pubmed:month | Dec | lld:pubmed |
| pubmed-article:17046818 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:PetersonPärtP | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:DingJaneJ | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:WangZheZ | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:DingHan-FeiHF | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:GunningWillia... | lld:pubmed |
| pubmed-article:17046818 | pubmed:author | pubmed-author:ZhangBaochunB | lld:pubmed |
| pubmed-article:17046818 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17046818 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:17046818 | pubmed:volume | 281 | lld:pubmed |
| pubmed-article:17046818 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17046818 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17046818 | pubmed:pagination | 38617-24 | lld:pubmed |
| pubmed-article:17046818 | pubmed:dateRevised | 2011-9-26 | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
| pubmed-article:17046818 | pubmed:meshHeading | pubmed-meshheading:17046818... | lld:pubmed |
