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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
25
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pubmed:dateCreated |
2006-10-23
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pubmed:abstractText |
New Zealand obese (NZO/HlLt) male mice develop polygenic diabetes and altered phosphatidylcholine metabolism. The gene encoding phosphatidylcholine transfer protein (PC-TP) is sited within the support interval for Nidd3, a recessive NZO-derived locus on Chromosome 11 identified by prior segregation analysis between NZO/HlLt and NON/Lt. Sequence analysis revealed that the NZO-derived PC-TP contained a non-synonymous point mutation that resulted in an Arg120His substitution, which was shared by the related NZB/BlNJ and NZW/LacJ mouse strains. Consistent with the structure-based predictions, functional studies demonstrated that Arg120His PC-TP was inactive, suggesting that this mutation contributes to the deficiencies in phosphatidylcholine metabolism observed in NZO mice.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-10322415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-10415339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-10500206,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-10542325,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-10802740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-11112525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-11343249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-11751880,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-11872687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-12055623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-12401879,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-12724317,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-15576839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-15628972,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-15919809,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-16750656,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-1883207,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-2025413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-5425297,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-7984417,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-861201,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-8645232,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-9703330,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-9741699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17046758-9927721
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
580
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5953-8
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pubmed:dateRevised |
2011-4-13
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pubmed:meshHeading |
pubmed-meshheading:17046758-Amino Acid Substitution,
pubmed-meshheading:17046758-Animals,
pubmed-meshheading:17046758-Base Sequence,
pubmed-meshheading:17046758-Chromosome Mapping,
pubmed-meshheading:17046758-DNA, Complementary,
pubmed-meshheading:17046758-Male,
pubmed-meshheading:17046758-Mice,
pubmed-meshheading:17046758-Mice, Inbred NZB,
pubmed-meshheading:17046758-Mice, Inbred Strains,
pubmed-meshheading:17046758-Mice, Obese,
pubmed-meshheading:17046758-Models, Molecular,
pubmed-meshheading:17046758-Phosphatidylcholines,
pubmed-meshheading:17046758-Phospholipid Transfer Proteins,
pubmed-meshheading:17046758-Point Mutation,
pubmed-meshheading:17046758-Polymorphism, Genetic,
pubmed-meshheading:17046758-Protein Conformation,
pubmed-meshheading:17046758-Species Specificity
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pubmed:year |
2006
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pubmed:articleTitle |
A polymorphism in New Zealand inbred mouse strains that inactivates phosphatidylcholine transfer protein.
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pubmed:affiliation |
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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