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rdf:type |
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lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0009402,
umls-concept:C0016360,
umls-concept:C0020792,
umls-concept:C0026882,
umls-concept:C0030705,
umls-concept:C0032659,
umls-concept:C0205314,
umls-concept:C0376249,
umls-concept:C0679622,
umls-concept:C0680730,
umls-concept:C1148554,
umls-concept:C1274040,
umls-concept:C1366555
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-1-3
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|
pubmed:abstractText |
Life-threatening toxic side-effects following 5-FU exposure have been related to deficiency of dihydropyrimidine dehydrogenase (DPD), the rate-limiting enzyme in its catabolism. We presently report a new DPYD gene SNP in a Spanish woman who died from multivisceral 5-FU-induced toxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0009-9120
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
40
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
11-7
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pubmed:meshHeading |
pubmed-meshheading:17046731-Adenine,
pubmed-meshheading:17046731-Aged,
pubmed-meshheading:17046731-Alleles,
pubmed-meshheading:17046731-Colorectal Neoplasms,
pubmed-meshheading:17046731-DNA, Complementary,
pubmed-meshheading:17046731-DNA Mutational Analysis,
pubmed-meshheading:17046731-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:17046731-Exons,
pubmed-meshheading:17046731-Fatal Outcome,
pubmed-meshheading:17046731-Female,
pubmed-meshheading:17046731-Fluorouracil,
pubmed-meshheading:17046731-Gene Frequency,
pubmed-meshheading:17046731-Humans,
pubmed-meshheading:17046731-Introns,
pubmed-meshheading:17046731-Mutation,
pubmed-meshheading:17046731-Pedigree,
pubmed-meshheading:17046731-Polymorphism, Single Nucleotide,
pubmed-meshheading:17046731-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:17046731-Sequence Analysis, DNA,
pubmed-meshheading:17046731-Thymine,
pubmed-meshheading:17046731-Uracil
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pubmed:year |
2007
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pubmed:articleTitle |
Identification of a novel mutation in the dihydropyrimidine dehydrogenase gene in a patient with a lethal outcome following 5-fluorouracil administration and the determination of its frequency in a population of 500 patients with colorectal carcinoma.
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pubmed:affiliation |
Department of Oncopharmacology and Pharmacogenetics, INSERM U564, Anti Cancer Centre Paul Papin, 2 rue Moll, 49933 Angers cedex 09, France. a.morel@unimedia.fr
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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