Linked Life Data

17046325

Source:http://linkedlifedata.com/resource/pubmed/id/17046325

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-11-13
pubmed:abstractText
The human body is protected against external pathogens by two immune systems: innate and acquired immunities. Whereas innate immunity exhibits immediate responses to external pathogens by recognizing pathogen-associated molecular patterns (PAMPs), adaptive immunity uses T cells to recognize and defend against pathogens by developing effector cells, antibodies and memory cells. Although each system seems to possess distinct activation mechanisms, interleukin-1 receptor-associated kinase (IRAK)-4 is essential for NF-kappaB activation in Toll-like receptor (TLR) and T-cell receptor (TCR) signaling pathways. This implies possible crosstalk between innate and acquired immunities, and evolutionary development that resulted in the use of innate signaling molecules by the acquired immune system. Here, we discuss the impact of these evolutionarily conserved molecules on innate and acquired immunity, and their potential as drug targets for the simultaneous modulation of both immunities.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1471-4906
pubmed:author
pubmed:issnType
Print
pubmed:volume
27
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
566-72
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
IRAK-4--a shared NF-kappaB activator in innate and acquired immunity.
pubmed:affiliation
Laboratory for Cell Signaling, RIKEN Research Center for Allergy and Immunology, 1-7-22 Suehiro-cho, Tsurumi-ku, Yokohama 230-0045, Japan. nobu@rcai.riken.jp
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't