Source:http://linkedlifedata.com/resource/pubmed/id/17044868
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
Pt 6
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pubmed:dateCreated |
2006-10-18
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pubmed:abstractText |
The human HS1,2 enhancer of the immunoglobulin (Ig) heavy chain 3' enhancer complex plays a central role in the regulation of Ig maturation and production. Four common alleles HS1,2-A*1, *2, *3, *4 are directly implicated with the transcription level and at least one of them, HS1, 2-A*2, seems to be related to immune disorders, such as coeliac disease, herpetiform dermatitis and Berger syndrome. Given their clinical significance it is of interest to know the distribution of HS1,2-A variants in populations from different continents, as well as to determine whether the polymorphism is associated to specific evolutionary factors. In this paper we report the distribution of the HS1,2-A polymorphism in 1098 individuals from various African, Asian and European populations. HS1,2-A*3 and HS1,2-A*4 alleles are at their highest frequencies among Africans, and HS1,2-A*2 is significantly lower in Africans in comparison with both Europeans and, to a lesser extent, Asians. Analysis of molecular variance of the allele frequencies indicates that the HS1,2-A polymorphism can be considered as a reliable anthropogenetic marker.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0003-4800
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pubmed:author |
pubmed-author:BiondiGG,
pubmed-author:CrawfordMM,
pubmed-author:FrancavillaRR,
pubmed-author:FrezzaDD,
pubmed-author:GiambraVV,
pubmed-author:GisladottirB KBK,
pubmed-author:GiufréMM,
pubmed-author:KilicS SSS,
pubmed-author:Martínez-LabargaCC,
pubmed-author:ModianoDD,
pubmed-author:RickardsOO,
pubmed-author:SimporéJJ,
pubmed-author:ZhelezovaGG
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pubmed:issnType |
Print
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pubmed:volume |
70
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
946-50
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17044868-African Continental Ancestry Group,
pubmed-meshheading:17044868-Asian Continental Ancestry Group,
pubmed-meshheading:17044868-Enhancer Elements, Genetic,
pubmed-meshheading:17044868-European Continental Ancestry Group,
pubmed-meshheading:17044868-Gene Frequency,
pubmed-meshheading:17044868-Genes, Immunoglobulin Heavy Chain,
pubmed-meshheading:17044868-Genetic Markers,
pubmed-meshheading:17044868-Genetics, Population,
pubmed-meshheading:17044868-Humans,
pubmed-meshheading:17044868-Models, Genetic,
pubmed-meshheading:17044868-Polymorphism, Genetic
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pubmed:year |
2006
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pubmed:articleTitle |
Immunoglobulin enhancer HS1,2 polymorphism: a new powerful anthropogenetic marker.
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pubmed:affiliation |
Dipartamento Biologia E. Calef, Università di Roma Tor Vergata, Viale della ricerca scientifica, 00133 Rome, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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