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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-3
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pubmed:dateCreated |
1991-3-20
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pubmed:abstractText |
Protective immunity against malaria is induced by immunization with irradiation-attenuated sporozoites. Here we report the isolation of cytolytic T-cell (CTL) clones from BALB/c (H-2d) mice immunized with either Plasmodium berghei or Plasmodium yoelii sporozoites. The epitopes recognized by these CTL can be mimicked by synthetic peptides corresponding to a homologous region in the CS proteins of both rodent malaria species. Both peptides are recognized by the CTL in the context of the same MHC class I molecule, H-2 Kd. In vivo adoptive transfer of the CTL clones into non-immune syngeneic mice protected them from a lethal challenge of infectious sporozoites.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0165-2478
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27-31
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1704348-Amino Acid Sequence,
pubmed-meshheading:1704348-Animals,
pubmed-meshheading:1704348-Antigens, Protozoan,
pubmed-meshheading:1704348-Cell Separation,
pubmed-meshheading:1704348-Clone Cells,
pubmed-meshheading:1704348-Disease Models, Animal,
pubmed-meshheading:1704348-Epitopes,
pubmed-meshheading:1704348-Immunotherapy, Adoptive,
pubmed-meshheading:1704348-Malaria,
pubmed-meshheading:1704348-Mice,
pubmed-meshheading:1704348-Mice, Inbred BALB C,
pubmed-meshheading:1704348-Molecular Sequence Data,
pubmed-meshheading:1704348-Peptide Fragments,
pubmed-meshheading:1704348-Plasmodium berghei,
pubmed-meshheading:1704348-Plasmodium yoelii,
pubmed-meshheading:1704348-Protozoan Proteins,
pubmed-meshheading:1704348-Spleen,
pubmed-meshheading:1704348-T-Lymphocytes, Cytotoxic
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pubmed:year |
1990
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pubmed:articleTitle |
Isolation and characterization of protective cytolytic T cells in a rodent malaria model system.
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pubmed:affiliation |
Ludwig Institute for Cancer Research, Lausanne Branch, Epalinges, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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