| pubmed-article:17043245 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17043245 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:17043245 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:17043245 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:17043245 | lifeskim:mentions | umls-concept:C0030956 | lld:lifeskim |
| pubmed-article:17043245 | lifeskim:mentions | umls-concept:C0215825 | lld:lifeskim |
| pubmed-article:17043245 | pubmed:issue | 43 | lld:pubmed |
| pubmed-article:17043245 | pubmed:dateCreated | 2006-10-25 | lld:pubmed |
| pubmed-article:17043245 | pubmed:abstractText | Adrenomedullin (AM) belongs to the calcitonin gene-related peptide (CGRP) family and is a well known potent vasodilator. We show here that AM is a powerful pain-inducing neuropeptide. AM-like immunoreactivity is widely distributed in both CGRP-containing and lectin IB4-binding nociceptors in dorsal root ganglion and axon terminals in the superficial dorsal horn of the rat spinal cord. Specific binding sites for the radioligand, [(125)I]AM13-52 as well as immunoreactivity for receptor markers such as the calcitonin receptor-like receptor and three receptor-activity-modifying proteins are localized in the superficial dorsal horn, demonstrating the existence of AM/CGRP receptors in this region. Intrathecal injection of rat AM1-50, dose- and time-dependently, induced long-lasting heat hyperalgesia and increased the phosphorylation of Akt and GSK3beta in the dorsal horn. Pre- and posttreatments with the AM receptor antagonist AM22-52 and PI3 kinase inhibitors (LY294002 and Wortmannin) significantly blocked or reversed AM-induced heat hyperalgesia. Pre- and posttreatments with AM22-52 and Wortmannin also significantly blocked or reversed intraplantar capsaicin-induced heat hyperalgesia. Taken together, our results demonstrate that AM acts as a pain-inducing peptide in the dorsal horn. By activating specific receptors (likely AM2) and the PI3K/Akt/GSK3beta signaling pathway, AM could play a significant role in long-lasting heat hypersensitivity and inflammatory heat hyperalgesia. | lld:pubmed |
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| pubmed-article:17043245 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17043245 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17043245 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17043245 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17043245 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:17043245 | pubmed:author | pubmed-author:ChabotJean-Gu... | lld:pubmed |
| pubmed-article:17043245 | pubmed:author | pubmed-author:MaWeiyaW | lld:pubmed |
| pubmed-article:17043245 | pubmed:author | pubmed-author:QuirionRemiR | lld:pubmed |
| pubmed-article:17043245 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17043245 | pubmed:day | 24 | lld:pubmed |
| pubmed-article:17043245 | pubmed:volume | 103 | lld:pubmed |
| pubmed-article:17043245 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17043245 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17043245 | pubmed:pagination | 16027-32 | lld:pubmed |
| pubmed-article:17043245 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:17043245 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17043245 | pubmed:articleTitle | A role for adrenomedullin as a pain-related peptide in the rat. | lld:pubmed |
| pubmed-article:17043245 | pubmed:affiliation | Douglas Hospital Research Center, and Department of Psychiatry, McGill University, Montreal, QC, Canada H4H 1R3. | lld:pubmed |
| pubmed-article:17043245 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17043245 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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