|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2007-3-26
|
|
pubmed:abstractText |
Extracellular inorganic pyrophosphate (ePPi) inhibits certain forms of pathological mineralization while promoting others. Three molecules involved in ePPi regulation are important candidates for the development of calcium pyrophosphate dihydrate chondrocalcinosis (CPPD CC). These include ANKH, ectonucleotide pyrophosphatase (ENPP1) and TNAP. We have previously showed that genetic variation in ANKH is a cause of autosomal dominant familial CC and also some sporadic cases of CPPD CC. We now investigate the possible role of ENPP1 and TNAP in CPPD CC.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
1462-0324
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
46
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
586-9
|
|
pubmed:dateRevised |
2007-9-6
|
|
pubmed:meshHeading |
pubmed-meshheading:17043047-Aged,
pubmed-meshheading:17043047-Carrier Proteins,
pubmed-meshheading:17043047-Chondrocalcinosis,
pubmed-meshheading:17043047-Gene Frequency,
pubmed-meshheading:17043047-Genetic Predisposition to Disease,
pubmed-meshheading:17043047-Genotype,
pubmed-meshheading:17043047-Humans,
pubmed-meshheading:17043047-Middle Aged,
pubmed-meshheading:17043047-Mutation,
pubmed-meshheading:17043047-Phosphoric Diester Hydrolases,
pubmed-meshheading:17043047-Polymorphism, Single Nucleotide,
pubmed-meshheading:17043047-Pyrophosphatases
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Investigation of the role of ENPP1 and TNAP genes in chondrocalcinosis.
|
|
pubmed:affiliation |
Oxford University Institute of Musculoskeletal Sciences, Botnar Research Centre, Nuffield Orthopaedic Centre, Oxford OX3 7LD, UK. yun@well.ox.ac.uk
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
