Source:http://linkedlifedata.com/resource/pubmed/id/17043021
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
11
|
| pubmed:dateCreated |
2006-11-3
|
| pubmed:abstractText |
The PRDM1 gene, a master regulator of plasma cells (PC), can generate two transcription factor isoforms: PRDI-BF1alpha and PRDI-BF1beta. The present study shows that purified human normal PC have a significantly lower levels of PRDI-BF1beta expression than that in tumoral PC isolated from multiple myeloma (MM) (0.06+/-0.01 and 0.25+/-0.05, respectively; p<0.001). The role of this finding in MM is discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Nov
|
| pubmed:issn |
1592-8721
|
| pubmed:author | |
| pubmed:issnType |
Electronic
|
| pubmed:volume |
91
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
1579-80
|
| pubmed:meshHeading |
pubmed-meshheading:17043021-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17043021-Humans,
pubmed-meshheading:17043021-Multiple Myeloma,
pubmed-meshheading:17043021-Plasma Cells,
pubmed-meshheading:17043021-Protein Isoforms,
pubmed-meshheading:17043021-Repressor Proteins,
pubmed-meshheading:17043021-Transcription Factors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
The expression of PRDI-BF1 beta isoform in multiple myeloma plasma cells.
|
| pubmed:publicationType |
Letter,
Comparative Study,
Research Support, Non-U.S. Gov't
|