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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1991-3-8
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pubmed:abstractText |
Asialofetuin-tacked liposomes (AF-liposomes) encapsulating interferon (IFN)-gamma were bound and internalized into a human hepatoma cell line, HepG2 cells, selectively through asialoglycoprotein receptor, but not non-tacked liposomes (N-liposomes). AF-liposomal IFN-gamma was more effective for inhibition of viral DNA replication in hepatitis B virus (HBV)-producing clone from HepG2 cells transfected with HBV-DNA than N-liposomal IFN-gamma. AF-liposomes may increase the therapeutic potential of IFN-gamma through asialoglycoprotein receptor in treating HBV-infected hepatocytes.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Asialoglycoprotein Receptor,
http://linkedlifedata.com/resource/pubmed/chemical/Asialoglycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Drug Carriers,
http://linkedlifedata.com/resource/pubmed/chemical/Fetuins,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Liposomes,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Interferon,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-Fetoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/asialofetuin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
31
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pubmed:volume |
174
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
839-45
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:1704230-Asialoglycoprotein Receptor,
pubmed-meshheading:1704230-Asialoglycoproteins,
pubmed-meshheading:1704230-Biological Transport,
pubmed-meshheading:1704230-Carcinoma, Hepatocellular,
pubmed-meshheading:1704230-Cell Line,
pubmed-meshheading:1704230-Drug Carriers,
pubmed-meshheading:1704230-Fetuins,
pubmed-meshheading:1704230-Hepatitis B virus,
pubmed-meshheading:1704230-Humans,
pubmed-meshheading:1704230-Interferon-gamma,
pubmed-meshheading:1704230-Kinetics,
pubmed-meshheading:1704230-Liposomes,
pubmed-meshheading:1704230-Liver Neoplasms,
pubmed-meshheading:1704230-Receptors, Immunologic,
pubmed-meshheading:1704230-Receptors, Interferon,
pubmed-meshheading:1704230-Recombinant Proteins,
pubmed-meshheading:1704230-Temperature,
pubmed-meshheading:1704230-Virus Replication,
pubmed-meshheading:1704230-alpha-Fetoproteins
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pubmed:year |
1991
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pubmed:articleTitle |
Specific uptake of asialofetuin-tacked liposomes encapsulating interferon-gamma by human hepatoma cells and its inhibitory effect on hepatitis B virus replication.
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pubmed:affiliation |
Tokyo College of Pharmacy, Japan.
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pubmed:publicationType |
Journal Article
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