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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-7
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pubmed:abstractText |
Persistent viral infections are a major health concern. One obstacle inhibiting the clearance of persistent infections is functional inactivation of antiviral T cells. Although such immunosuppression occurs rapidly after infection, the mechanisms that induce the loss of T-cell activity and promote viral persistence are unknown. Herein we document that persistent viral infection in mice results in a significant upregulation of interleukin (IL)-10 by antigen-presenting cells, leading to impaired T-cell responses. Genetic removal of Il10 resulted in the maintenance of robust effector T-cell responses, the rapid elimination of virus and the development of antiviral memory T-cell responses. Therapeutic administration of an antibody that blocks the IL-10 receptor restored T-cell function and eliminated viral infection. Thus, we identify a single molecule that directly induces immunosuppression leading to viral persistence and demonstrate that a therapy to neutralize IL-10 results in T-cell recovery and the prevention of viral persistence.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-10604568,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-10790425,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11029005,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11067874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11124848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11244051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11369878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11479623,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11507186,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11679915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-11714747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-12663797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-12759441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-14635055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15034033,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15057302,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15128934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15187167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15280419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15531885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-15937058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16006191,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16051844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16116467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16382236,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16499662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16611188,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16710479,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-16921384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-17088891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-17570238,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-1827484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-1840619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-6332167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-7676639,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-7815484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-7911534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-7966595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-8113410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-8627058,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-8691133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-8695805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-8707283,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-9021963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-9448700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-9565631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-9636366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17041596-9858507
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1078-8956
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1301-9
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:17041596-Animals,
pubmed-meshheading:17041596-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17041596-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17041596-Flow Cytometry,
pubmed-meshheading:17041596-HIV,
pubmed-meshheading:17041596-Hepacivirus,
pubmed-meshheading:17041596-Immunologic Memory,
pubmed-meshheading:17041596-Interleukin-10,
pubmed-meshheading:17041596-Lymphocytic choriomeningitis virus,
pubmed-meshheading:17041596-Mice,
pubmed-meshheading:17041596-Receptors, Interleukin-10,
pubmed-meshheading:17041596-Reverse Transcriptase Polymerase Chain Reaction
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pubmed:year |
2006
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pubmed:articleTitle |
Interleukin-10 determines viral clearance or persistence in vivo.
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pubmed:affiliation |
Viral Immunobiology Laboratory, Molecular and Integrative Neuroscience Department, Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037, USA. dbrooks@scripps.edu
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pubmed:publicationType |
Journal Article
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