Source:http://linkedlifedata.com/resource/pubmed/id/17041236
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
12
|
| pubmed:dateCreated |
2006-11-19
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| pubmed:abstractText |
Increasing evidence supports a role for altered T helper 1 (Th1)-Th2 cytokine balance in idiopathic recurrent spontaneous abortion (RSA). The aim of this study was to investigate the association of the interleukin 10 (IL-10) promoter polymorphisms -592C/A, -819C/T and -1082A/G with RSA. Women (n = 350) with at least three consecutive spontaneous abortions (RSA cases) and 200 control women with at least two successful pregnancies were included. The frequency of the -819T allele [P = 0.05, odds ratio (OR) = 1.51], but not other single-nucleotide polymorphisms (SNPs), was higher among RSA patients. Complete linkage disequilibrium (LD) was seen between -592C and -819C and -1082G alleles, as well as between -592A and -819T and between -819C and -1082G alleles only among patients. Although the genotype frequencies (except for -819C/C) of the three polymorphisms were comparable between patients and controls, higher frequency of -592A/-819T/-1082A haplotype (OR = 4.01, 95% CI = 1.83-7.95) was seen in cases versus controls. Regression analysis indicated that, after adjusting for potential variables, -592C/A (OR = 3.32, 95% CI = 1.76-6.27) and -819C/T (OR = 5.06, 95% CI = 2.59-9.91) were associated with exclusively early but not exclusively late RSA, where negative association for both was noted. This supports the notion of involvement of IL-10-592C/A and -819C/T polymorphisms as inherited risk factors of idiopathic RSA.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Dec
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| pubmed:issn |
1360-9947
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
12
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
771-6
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:17041236-Abortion, Habitual,
pubmed-meshheading:17041236-Adult,
pubmed-meshheading:17041236-Alleles,
pubmed-meshheading:17041236-Case-Control Studies,
pubmed-meshheading:17041236-Female,
pubmed-meshheading:17041236-Gene Frequency,
pubmed-meshheading:17041236-Genetic Predisposition to Disease,
pubmed-meshheading:17041236-Genotype,
pubmed-meshheading:17041236-Gestational Age,
pubmed-meshheading:17041236-Haplotypes,
pubmed-meshheading:17041236-Humans,
pubmed-meshheading:17041236-Interleukin-10,
pubmed-meshheading:17041236-Linkage Disequilibrium,
pubmed-meshheading:17041236-Odds Ratio,
pubmed-meshheading:17041236-Polymorphism, Single Nucleotide,
pubmed-meshheading:17041236-Pregnancy,
pubmed-meshheading:17041236-Promoter Regions, Genetic,
pubmed-meshheading:17041236-Retrospective Studies,
pubmed-meshheading:17041236-Risk Factors,
pubmed-meshheading:17041236-Th1 Cells,
pubmed-meshheading:17041236-Th2 Cells,
pubmed-meshheading:17041236-Tunisia
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| pubmed:year |
2006
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| pubmed:articleTitle |
Association of -592C/A, -819C/T and -1082A/G interleukin-10 promoter polymorphisms with idiopathic recurrent spontaneous abortion.
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| pubmed:affiliation |
Research unit of Haematological and Autoimmune diseases, Faculty of Pharmacy, Monastir, Center University, France.
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| pubmed:publicationType |
Journal Article
|