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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1991-3-14
|
| pubmed:abstractText |
Seven patients with hyperthyroidism due to a TSH-secreting pituitary macroadenoma have been observed of a total of 800 patients with pituitary tumors over a period of 15 yr. Serum TSH levels varied between 1.1-36.3 mU/L. The serum alpha-subunit level was low in 1 case, while in 4 other cases the concentration was elevated and varied between 3.7-7.8 micrograms/L. Serum TSH beta levels were normal in the 4 cases in which it was determined. Serum GH or PRL levels were elevated in 5 cases. In 1 patient the cosecretion of TSH, GH, and PRL was confirmed by immunocytochemical examination. Serum TSH and alpha-subunit responses to TRH, GnRH, CRF, GRF, dexamethasone, methimazole, T3, and bromocriptine administration were variable when studied. Serum TSH and alpha-subunit circadian rhythms were absent in 1 case and inverted in another. A serum alpha-subunit pulsatility without TSH pulses was observed in 1 patient. Five patients underwent transsphenoidal adenomectomy. Three of 4 patients operated on in our center were cured, but a recurrence of the adenoma was found in 1 of them after 5 yr. The fifth patient was not cured. Treatment with octreotide in 3 patients resulted in normalization of serum TSH, GH, and thyroid hormones levels. Cosecretion of PRL in 1 case and alpha-subunit in 2 cases was also inhibited. Partial tachyphylaxis occurred in 1 patient. In summary, heterogeneity in clinical presentation, hormonal expression, and therapeutic response appears to characterize these TSH-secreting adenomas.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Bromocriptine,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoprotein Hormones, alpha Subunit,
http://linkedlifedata.com/resource/pubmed/chemical/Growth Hormone,
http://linkedlifedata.com/resource/pubmed/chemical/Methimazole,
http://linkedlifedata.com/resource/pubmed/chemical/Octreotide,
http://linkedlifedata.com/resource/pubmed/chemical/Prolactin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin,
http://linkedlifedata.com/resource/pubmed/chemical/Thyrotropin-Releasing Hormone
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
0021-972X
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
72
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
477-83
|
| pubmed:dateRevised |
2005-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:1704011-Adenoma,
pubmed-meshheading:1704011-Adolescent,
pubmed-meshheading:1704011-Adult,
pubmed-meshheading:1704011-Aged,
pubmed-meshheading:1704011-Aged, 80 and over,
pubmed-meshheading:1704011-Bromocriptine,
pubmed-meshheading:1704011-Circadian Rhythm,
pubmed-meshheading:1704011-Female,
pubmed-meshheading:1704011-Glycoprotein Hormones, alpha Subunit,
pubmed-meshheading:1704011-Growth Hormone,
pubmed-meshheading:1704011-Humans,
pubmed-meshheading:1704011-Hyperthyroidism,
pubmed-meshheading:1704011-Male,
pubmed-meshheading:1704011-Methimazole,
pubmed-meshheading:1704011-Middle Aged,
pubmed-meshheading:1704011-Octreotide,
pubmed-meshheading:1704011-Pituitary Neoplasms,
pubmed-meshheading:1704011-Prolactin,
pubmed-meshheading:1704011-Thyrotropin,
pubmed-meshheading:1704011-Thyrotropin-Releasing Hormone
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
Thyrotropin-secreting pituitary adenomas: report of seven cases.
|
| pubmed:affiliation |
Department of Endocrinology, University of Liège, Belgium.
|
| pubmed:publicationType |
Journal Article,
Case Reports
|