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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-13
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pubmed:abstractText |
ICOS/B7RP-1 is a new member of the CD28/B7 family of costimulatory molecules and plays differential roles in autoimmune diseases. In this study, we examined the role of ICOS/B7RP-1 pathway in the pathogenesis of mouse experimental autoimmune uveoretinitis (EAU), an animal model of human autoimmune uveitis. ICOS expression was found on infiltrating CD4+ T cells in the region of the retina in EAU-induced mice. The anti-B7RP-1 monoclonal antibody (mAb)-treated or ICOS-deficient mice showed a substantial reduction of disease scores. Blockade of ICOS/B7RP-1 interaction during the effector phase ameliorated the disease, whereas its blockade during the induction phase exhibited no significant effect. Moreover, administration of anti-B7RP-1 mAb effectively ameliorated the disease induced by adoptive transfer of pathogenic T cells. The anti-B7RP-1 mAb treatment inhibited the expansion and/or effector function of pathogenic T cells, given that proliferative response and IFN-gamma production by lymph node cells were reduced upon restimulation with the antigen peptide in vitro. These results suggest that the ICOS/B7RP-1 interaction plays a critical role in the pathogenesis of uveitis. We also indicated that ICOS-mediated costimulation plays differential roles in EAU and experimental autoimmune encephalomyelitis, which is also a Th1 disease induced in the same manner as EAU.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/ICOS protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Icos protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-gamma
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0014-2980
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pubmed:author |
pubmed-author:AkibaHisayaH,
pubmed-author:HattoriTakaakiT,
pubmed-author:KezukaTakeshiT,
pubmed-author:OkumuraKoK,
pubmed-author:OkunukiYokoY,
pubmed-author:TakeuchiAyaA,
pubmed-author:TakeuchiMasaruM,
pubmed-author:UsuiMasahikoM,
pubmed-author:UsuiYoshihikoY,
pubmed-author:YagitaHideoH,
pubmed-author:YamazakiTomohideT
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pubmed:issnType |
Print
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pubmed:volume |
36
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3071-81
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17039566-Adoptive Transfer,
pubmed-meshheading:17039566-Animals,
pubmed-meshheading:17039566-Antibodies, Monoclonal,
pubmed-meshheading:17039566-Antigens, CD80,
pubmed-meshheading:17039566-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:17039566-Autoimmune Diseases,
pubmed-meshheading:17039566-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17039566-Disease Models, Animal,
pubmed-meshheading:17039566-Genetic Predisposition to Disease,
pubmed-meshheading:17039566-Inducible T-Cell Co-Stimulator Ligand,
pubmed-meshheading:17039566-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:17039566-Interferon-gamma,
pubmed-meshheading:17039566-Lymph Nodes,
pubmed-meshheading:17039566-Lymphocyte Activation,
pubmed-meshheading:17039566-Mice,
pubmed-meshheading:17039566-Mice, Mutant Strains,
pubmed-meshheading:17039566-Retina,
pubmed-meshheading:17039566-Retinitis,
pubmed-meshheading:17039566-Uveitis
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pubmed:year |
2006
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pubmed:articleTitle |
The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.
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pubmed:affiliation |
Department of Immunology, Juntendo University School of Medicine, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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