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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Receptor for advanced glycation end products (AGEs) (RAGE) plays a central role in the process of plaque rupture in diabetic patients. Recently, it has been reported that RAGE may be downregulated by improving glycemic control. In contrast, despite being well known that RAGE may be induced in human vessels in a glucose-independent fashion, also by myeloperoxidase (MPO)-dependent AGE generation, no data exist regarding the possibility of a pharmacological modulation of glucose-independent RAGE generation. Thus, the aim of this study was to characterize the effect of simvastatin on the expression of RAGE and RAGE-dependent plaque-destabilizing genes in human atherosclerotic plaques.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anticholesteremic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Glycosylation End Products, Advanced,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Matrix Metalloproteinase 9,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/NF-kappa B,
http://linkedlifedata.com/resource/pubmed/chemical/PTGS2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Peroxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Simvastatin,
http://linkedlifedata.com/resource/pubmed/chemical/advanced glycosylation end-product...
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1524-4636
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pubmed:author |
pubmed-author:BeiRobertoR,
pubmed-author:ChiarelliFrancescoF,
pubmed-author:CipolloneFrancescoF,
pubmed-author:CuccurulloChiaraC,
pubmed-author:CuccurulloFrancoF,
pubmed-author:De CesareDomenicoD,
pubmed-author:Di FrancescoAndreaA,
pubmed-author:FaziaMaria LuigiaML,
pubmed-author:IezziAnnalisaA,
pubmed-author:MezzettiAndreaA,
pubmed-author:MuraroRaffaellaR,
pubmed-author:SchmidtAnn MarieAM,
pubmed-author:SpigonardoFrancescoF,
pubmed-author:UcchinoSanteS
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pubmed:issnType |
Electronic
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pubmed:volume |
26
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2716-23
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pubmed:dateRevised |
2007-7-25
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pubmed:meshHeading |
pubmed-meshheading:17038636-Aged,
pubmed-meshheading:17038636-Anticholesteremic Agents,
pubmed-meshheading:17038636-Carotid Stenosis,
pubmed-meshheading:17038636-Cells, Cultured,
pubmed-meshheading:17038636-Cyclooxygenase 2,
pubmed-meshheading:17038636-Diabetes Mellitus, Type 2,
pubmed-meshheading:17038636-Female,
pubmed-meshheading:17038636-Gene Expression Regulation,
pubmed-meshheading:17038636-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17038636-Glucose,
pubmed-meshheading:17038636-Glycosylation End Products, Advanced,
pubmed-meshheading:17038636-Humans,
pubmed-meshheading:17038636-Macrophages,
pubmed-meshheading:17038636-Male,
pubmed-meshheading:17038636-Matrix Metalloproteinase 2,
pubmed-meshheading:17038636-Matrix Metalloproteinase 9,
pubmed-meshheading:17038636-Membrane Proteins,
pubmed-meshheading:17038636-NF-kappa B,
pubmed-meshheading:17038636-Peroxidase,
pubmed-meshheading:17038636-Receptors, Immunologic,
pubmed-meshheading:17038636-Simvastatin
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pubmed:year |
2006
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pubmed:articleTitle |
Suppression of RAGE as a basis of simvastatin-dependent plaque stabilization in type 2 diabetes.
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pubmed:affiliation |
Atherosclerosis, Hypertension and Dyslipidemia Unit, G.d'Annunzio University of Chieti-Pescara, Italy.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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