| pubmed-article:17038589 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17038589 | lifeskim:mentions | umls-concept:C1704689 | lld:lifeskim |
| pubmed-article:17038589 | lifeskim:mentions | umls-concept:C0035668 | lld:lifeskim |
| pubmed-article:17038589 | lifeskim:mentions | umls-concept:C1155328 | lld:lifeskim |
| pubmed-article:17038589 | pubmed:issue | 5801 | lld:pubmed |
| pubmed-article:17038589 | pubmed:dateCreated | 2006-11-10 | lld:pubmed |
| pubmed-article:17038589 | pubmed:abstractText | Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself. | lld:pubmed |
| pubmed-article:17038589 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17038589 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:17038589 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:17038589 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17038589 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17038589 | pubmed:issn | 1095-9203 | lld:pubmed |
| pubmed-article:17038589 | pubmed:author | pubmed-author:TanChoon... | lld:pubmed |
| pubmed-article:17038589 | pubmed:author | pubmed-author:LiljeströmPet... | lld:pubmed |
| pubmed-article:17038589 | pubmed:author | pubmed-author:SchulzOliverO | lld:pubmed |
| pubmed-article:17038589 | pubmed:author | pubmed-author:Reis e... | lld:pubmed |
| pubmed-article:17038589 | pubmed:author | pubmed-author:WeberFriedema... | lld:pubmed |
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| pubmed-article:17038589 | pubmed:author | pubmed-author:NäslundTanja... | lld:pubmed |
| pubmed-article:17038589 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:17038589 | pubmed:day | 10 | lld:pubmed |
| pubmed-article:17038589 | pubmed:volume | 314 | lld:pubmed |
| pubmed-article:17038589 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17038589 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17038589 | pubmed:pagination | 997-1001 | lld:pubmed |
| pubmed-article:17038589 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:17038589 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17038589 | pubmed:articleTitle | RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates. | lld:pubmed |
| pubmed-article:17038589 | pubmed:affiliation | Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK. | lld:pubmed |
| pubmed-article:17038589 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17038589 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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