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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5801
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pubmed:dateCreated |
2006-11-10
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pubmed:abstractText |
Double-stranded RNA (dsRNA) produced during viral replication is believed to be the critical trigger for activation of antiviral immunity mediated by the RNA helicase enzymes retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5). We showed that influenza A virus infection does not generate dsRNA and that RIG-I is activated by viral genomic single-stranded RNA (ssRNA) bearing 5'-phosphates. This is blocked by the influenza protein nonstructured protein 1 (NS1), which is found in a complex with RIG-I in infected cells. These results identify RIG-I as a ssRNA sensor and potential target of viral immune evasion and suggest that its ability to sense 5'-phosphorylated RNA evolved in the innate immune system as a means of discriminating between self and nonself.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DDX58 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/DEAD-box RNA Helicases,
http://linkedlifedata.com/resource/pubmed/chemical/INS1 protein, influenza virus,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphates,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Double-Stranded,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/RNA Caps,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Viral Nonstructural Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1095-9203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
10
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pubmed:volume |
314
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
997-1001
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17038589-Animals,
pubmed-meshheading:17038589-Cell Line,
pubmed-meshheading:17038589-Cells, Cultured,
pubmed-meshheading:17038589-Cytoplasm,
pubmed-meshheading:17038589-DEAD-box RNA Helicases,
pubmed-meshheading:17038589-Dendritic Cells,
pubmed-meshheading:17038589-Encephalomyocarditis virus,
pubmed-meshheading:17038589-Genome, Viral,
pubmed-meshheading:17038589-Humans,
pubmed-meshheading:17038589-Immunity, Innate,
pubmed-meshheading:17038589-Influenza A virus,
pubmed-meshheading:17038589-Interferon-alpha,
pubmed-meshheading:17038589-Interferon-beta,
pubmed-meshheading:17038589-Mice,
pubmed-meshheading:17038589-Mice, Inbred C57BL,
pubmed-meshheading:17038589-Phosphates,
pubmed-meshheading:17038589-Phosphorylation,
pubmed-meshheading:17038589-RNA, Double-Stranded,
pubmed-meshheading:17038589-RNA, Viral,
pubmed-meshheading:17038589-RNA Caps,
pubmed-meshheading:17038589-Recombinant Fusion Proteins,
pubmed-meshheading:17038589-Transfection,
pubmed-meshheading:17038589-Vesicular stomatitis Indiana virus,
pubmed-meshheading:17038589-Viral Nonstructural Proteins,
pubmed-meshheading:17038589-Virus Replication
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pubmed:year |
2006
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pubmed:articleTitle |
RIG-I-mediated antiviral responses to single-stranded RNA bearing 5'-phosphates.
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pubmed:affiliation |
Immunobiology Laboratory, Cancer Research UK, London Research Institute, London WC2A 3PX, UK.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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