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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
43
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pubmed:dateCreated |
2006-10-25
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pubmed:databankReference |
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pubmed:abstractText |
Protein synthesis requires the accurate positioning of mRNA and tRNA in the peptidyl-tRNA site of the ribosome. Here we describe x-ray crystal structures of the intact bacterial ribosome from Escherichia coli in a complex with mRNA and the anticodon stem-loop of P-site tRNA. At 3.5-A resolution, these structures reveal rearrangements in the intact ribosome that clamp P-site tRNA and mRNA on the small ribosomal subunit. Binding of the anticodon stem-loop of P-site tRNA to the ribosome is sufficient to lock the head of the small ribosomal subunit in a single conformation, thereby preventing movement of mRNA and tRNA before mRNA decoding.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11014183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11092927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11283358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11296253,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11869452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-11909526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-12464183,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-12554856,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-14172630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-14536072,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-15165228,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-15299374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-15308780,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-15574334,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16116437,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16243353,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16272117,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16307924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16307925,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16314459,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-16530465,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-2025413,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-2430725,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-3524675,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-6813860,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-7528943,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-807580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17038497-9757107
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
103
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
15830-4
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:17038497-Base Sequence,
pubmed-meshheading:17038497-Crystallography, X-Ray,
pubmed-meshheading:17038497-Escherichia coli,
pubmed-meshheading:17038497-Models, Molecular,
pubmed-meshheading:17038497-Nucleic Acid Conformation,
pubmed-meshheading:17038497-Protein Binding,
pubmed-meshheading:17038497-RNA, Messenger,
pubmed-meshheading:17038497-RNA, Transfer,
pubmed-meshheading:17038497-Ribosomal Proteins,
pubmed-meshheading:17038497-Ribosomes
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pubmed:year |
2006
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pubmed:articleTitle |
Structural basis for mRNA and tRNA positioning on the ribosome.
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pubmed:affiliation |
Department of Molecular and Cell Biology, and Chemistry, University of California, Berkeley, CA 94720, USA.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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