Linked Life Data

1703663

Source:http://linkedlifedata.com/resource/pubmed/id/1703663

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1991-3-6
pubmed:abstractText
The role of substance P (SP) in the regulation of sympathetic outflow to the cardiovascular system was assessed. Intrathecal injection(ith) of capsaicin caused a release of SP from the spinal cord and resulted in an increase in blood pressure and heart rate accompanied by an elevation of plasma adrenaline and noradrenaline. This pressor response was blocked by ith SP antagonist D-Pro2, D-Phe7, D-Trp9-SP or antiserum against SP. The immunohistochemical study showed that the SP-like immunoreactivity in T-8 of the spinal cord was decreased as the amount of capsaicin administrated was increased. Spinal cord transection had no effect on pressor responses caused by ith 10 micrograms capsaicin. These results suggest that SP transmits excitatory information to the cardiovascular system via spinal sympathetic pathway.
pubmed:language
chi
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0371-0874
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
446-52
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1990
pubmed:articleTitle
[Effect of capsaicin on the release of substance P from spinal cord and blood pressure].
pubmed:affiliation
Department of Physiology, Peking Union Medical College, Beijing.
pubmed:publicationType
Journal Article, English Abstract, Research Support, Non-U.S. Gov't