Source:http://linkedlifedata.com/resource/pubmed/id/17036221
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
2006-12-4
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pubmed:abstractText |
We conducted a pilot study to evaluate the feasibility of reduced-intensity cord blood transplantation (RI-CBT) using a non-total body irradiation (TBI) regimen in adult patients with advanced hematologic malignancies. Seventeen patients with a median age of 58 years (range, 38-74) underwent RI-CBT at Tsukuba Memorial Hospital between April 2004 and November 2005. Preparative regimens were fludarabine 30 mg/m(2) for 6 days, and busulfan 4 mg/kg for 2 days. Tacrolimus was used for prophylaxis of graft-vs-host disease (GVHD). Median numbers of infused total nucleated were 2.6 x 10(7)/kg (range, 2.0-3.3). HLA disparity was found in 2/6 antigens (n=16) and 1/6 antigens (n=1). Underlying diseases progressed despite preparative regimens in four patients. Of the remaining 13 patients, nine patients achieved engraftment at a median of day 18 (range, 17-28). Six of the nine patients with engraftment achieved complete donor-type chimerism by day 100. Six patients were alive in remission at median follow-up of 13.1 months (range, 1.0-19.0). This study demonstrated the feasibility of RI-CBT using a non-TBI regimen in adults. When disease progression is controlled by the preparative regimen, RI-CBT carries a clinically significant graft-vs-tumor effect. Further studies are required to identify patients who benefit from this regimen.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1432-0584
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pubmed:author |
pubmed-author:HoriAkikoA,
pubmed-author:KamiMasahiroM,
pubmed-author:KobayashiKazuhikoK,
pubmed-author:KomatsuTsunehikoT,
pubmed-author:KuritaNaokiN,
pubmed-author:KusakabeManabuM,
pubmed-author:MatsumuraTomokoT,
pubmed-author:MurashigeNaokoN,
pubmed-author:NarimatsuHirotoH,
pubmed-author:TanakaYujiY,
pubmed-author:YoshimiAiA,
pubmed-author:YujiKoichiroK
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pubmed:issnType |
Electronic
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-54
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pubmed:meshHeading |
pubmed-meshheading:17036221-Adult,
pubmed-meshheading:17036221-Aged,
pubmed-meshheading:17036221-Busulfan,
pubmed-meshheading:17036221-Cord Blood Stem Cell Transplantation,
pubmed-meshheading:17036221-Drug Therapy, Combination,
pubmed-meshheading:17036221-Feasibility Studies,
pubmed-meshheading:17036221-Female,
pubmed-meshheading:17036221-Humans,
pubmed-meshheading:17036221-Male,
pubmed-meshheading:17036221-Middle Aged,
pubmed-meshheading:17036221-Myeloablative Agonists,
pubmed-meshheading:17036221-Pilot Projects,
pubmed-meshheading:17036221-Transplantation, Homologous,
pubmed-meshheading:17036221-Transplantation Conditioning,
pubmed-meshheading:17036221-Treatment Outcome,
pubmed-meshheading:17036221-Vidarabine,
pubmed-meshheading:17036221-Whole-Body Irradiation
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pubmed:year |
2007
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pubmed:articleTitle |
Successful engraftment of mismatched unrelated cord blood transplantation following reduced intensity preparative regimen using fludarabine and busulfan.
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pubmed:affiliation |
Department of Hematology, Tsukuba Memorial Hospital, Tsukuba, Japan.
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pubmed:publicationType |
Journal Article,
Clinical Trial
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